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Pilot Study of the Effect of Baclofen and Bromocriptine on Luteinizing Hormone Secretion in Pubertal Children

This study has been completed.
University of Michigan
Information provided by:
Office of Rare Diseases (ORD) Identifier:
First received: February 24, 2000
Last updated: June 23, 2005
Last verified: December 2001

OBJECTIVES: I. Evaluate the effect of bromocriptine on luteinizing hormone (LH) secretion by suppression of prolactin and stimulation of dopaminergic receptors in early pubertal boys and girls.

II. Evaluate the effect of baclofen on LH secretion by stimulation of gamma-aminobutyric acid receptors in early pubertal boys and girls.

Growth Disorders

Study Type: Observational
Study Design: Primary Purpose: Screening

Resource links provided by NLM:

Further study details as provided by Office of Rare Diseases (ORD):

Estimated Enrollment: 4
Study Start Date: June 1995
Detailed Description:


Participants receive bromocriptine or baclofen followed by nocturnal measurements of luteinizing hormone, growth hormone, and sex steroids. Pituitary reserve is evaluated with the administration of gonadotropin-releasing hormone, and in children undergoing assessment of short stature, standard provocative stimuli.


Ages Eligible for Study:   up to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
  • Short stature and/or constitutional growth delay
  • No epilepsy or risk of epilepsy
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Please refer to this study by its identifier: NCT00004793

Sponsors and Collaborators
National Center for Research Resources (NCRR)
University of Michigan
Study Chair: Carol M. Foster University of Michigan
  More Information Identifier: NCT00004793     History of Changes
Other Study ID Numbers: 199/11923
Study First Received: February 24, 2000
Last Updated: June 23, 2005

Keywords provided by Office of Rare Diseases (ORD):
constitutional growth delay
endocrine disorders
rare disease

Additional relevant MeSH terms:
Growth Disorders
Pathologic Processes processed this record on September 21, 2017