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Electromyography to Diagnose Neuromuscular Disorders

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00004553
First Posted: February 7, 2000
Last Update Posted: March 4, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Institutes of Health Clinical Center (CC)
  Purpose

This study will investigate problems with muscle weakness and control using electromyography-a test of nerve-muscle cell communication. Advanced techniques called single fiber electromyography and macro-electromyography, which evaluate individual muscle fibers, will be used. Besides aiding in diagnosis, these tests provide information about disease progression that may be useful in guiding therapy.

Adult patients with suspected neurological disorders of muscle control and weakness may be eligible for this study. Normal volunteers may also participate. For the electromyography procedure, a special needle is inserted into a muscle. The patient will slightly tense the muscle and maintain the tension while electrical signals from the muscle fibers are being recorded. The electrical signals are played through a loudspeaker, providing feedback to help the patient tense the muscle the appropriate amount. The test, which is usually done for only one muscle, takes 1 to 2 hours. If needed, short breaks can be taken.

If the patient cannot maintain tension in the muscle for the entire test period, a nerve will be stimulated to activate the muscle. A thin needle is inserted near the nerve, and a series of small electrical shocks are given to activate a nerve fiber. The electromyography needle is inserted into the muscle to measure the response, as described above.

A neurologist receiving specialized training in clinical neurophysiology will do the electromyography procedure under the direct supervision of an experienced neurologist.


Condition Intervention
Healthy Neuromuscular Disease Postpoliomyelitis Syndrome Procedure: Electromyography

Study Type: Interventional
Official Title: Diagnosis of Neuromuscular Disorders With Specialized Electromyographic Studies

Resource links provided by NLM:


Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 30
Study Start Date: February 2000
Estimated Study Completion Date: November 2005
Detailed Description:
This is a training protocol to enable fellows in clinical neurophysiology to learn and perform technically advanced electrodiagnostic studies, such as single fiber EMG and macro EMG, on patients with neuromuscular diseases.
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

INCLUSION CRITERIA:

Adult patients with weakness or motor dysfunction: 8/year.

Normal volunteers, adults: 2/year.

EXCLUSION CRITERIA:

Anticoagulation or uncorrected bleeding disorder.

Children are not optimal subjects for fellows undergoing training in these techniques and will be excluded.

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00004553


Locations
United States, Maryland
National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
National Institute of Neurological Disorders and Stroke (NINDS)
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00004553     History of Changes
Other Study ID Numbers: 000072
00-N-0072
First Submitted: February 4, 2000
First Posted: February 7, 2000
Last Update Posted: March 4, 2008
Last Verified: November 2005

Keywords provided by National Institutes of Health Clinical Center (CC):
Single Fiber EMG
Macro-EMG
Myasthenia
Post-Polio Syndrome
Neuromuscular Transmission
Motor Dysfunction
Neuromuscular Disorder

Additional relevant MeSH terms:
Postpoliomyelitis Syndrome
Neuromuscular Diseases
Nervous System Diseases
Poliomyelitis
Enterovirus Infections
Picornaviridae Infections
RNA Virus Infections
Virus Diseases
Muscular Disorders, Atrophic
Muscular Diseases
Musculoskeletal Diseases
Myelitis
Central Nervous System Infections
Central Nervous System Diseases
Spinal Cord Diseases
Neurodegenerative Diseases