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Longitudinal and Biological Study of Childhood Disintegrative Disorder

This study has been terminated.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00004458
First Posted: October 19, 1999
Last Update Posted: December 9, 2005
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Yale University
Information provided by:
Office of Rare Diseases (ORD)
  Purpose

OBJECTIVES:

I. Compare the developmental course (language acquisition, diagnostic stability, predictors of outcome, and restricted interests and behaviors) of childhood disintegrative disorder versus autism and non-autistic developmental delays.

II. Collect data on molecular genetics of proband and family members.


Condition
Pervasive Child Development Disorders Autism

Study Type: Observational
Study Design: Primary Purpose: Screening
Time Perspective: Longitudinal

Resource links provided by NLM:


Further study details as provided by Office of Rare Diseases (ORD):

Estimated Enrollment: 220
Study Start Date: May 1997
Detailed Description:

PROTOCOL OUTLINE:

Patients are evaluated with the following questionnaires at ages 2-3 years and again at ages 5-9: The Autism Diagnostic Interview (ADI); The Autism Diagnostic Observation Schedule (ADOS); Assessment of cognitive functioning; Expressive and receptive language; Adaptive functioning; Measures of burden and functional assessment; The Aberrant Behavior Checklist; The Connors Rating Scale - Parent and Teacher version; and Autism Behavior Checklist

An MRI and EEG are performed, and blood samples are collected from patients and family members for molecular genetic studies.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   2 Years to 9 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria
  • Psychologically diagnosed (DSM-IV) as Childhood Disintegrative Disorder
  • No known genetic or medical syndrome (Down syndrome or cerebral palsy)
  • Must speak English
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00004458


Locations
United States, Connecticut
Yale Child Study Center
New Haven, Connecticut, United States, 06520
United States, Illinois
University of Chicago Cancer Research Center
Chicago, Illinois, United States, 60637
Sponsors and Collaborators
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Yale University
Investigators
Study Chair: Fred Volkmar Yale University
  More Information

Publications:
Volkmar FR, Klin A, Marans WD, et al.: Childhood disintegrative disorder. In: Cohen DJ, Volkmar FR.: Handbook of autism and pervasive developmental disorders. 2nd ed., New York, NY: John Wiley, 1997, pp 47-59.

ClinicalTrials.gov Identifier: NCT00004458     History of Changes
Other Study ID Numbers: 199/13682
YALE-5P01HD0300830
YALE-HIC-5895
First Submitted: October 18, 1999
First Posted: October 19, 1999
Last Update Posted: December 9, 2005
Last Verified: October 2003

Keywords provided by Office of Rare Diseases (ORD):
autism
childhood disintegrative disorder
neurologic and psychiatric disorders
rare disease

Additional relevant MeSH terms:
Disease
Developmental Disabilities
Child Development Disorders, Pervasive
Pathologic Processes
Neurodevelopmental Disorders
Mental Disorders