Pilot Randomized Study of Paromomycin (Aminosidine) vs Streptomycin for Uncomplicated Pulmonary Tuberculosis
OBJECTIVES: I. Compare the pharmacokinetics and early bactericidal activity of paromomycin (aminosidine) vs streptomycin for the treatment of uncomplicated pulmonary tuberculosis.
II. Compare the tolerability of these two drugs in these patients. III. Establish the relationships between achieved serum concentration, minimal inhibitory concentration, and early bactericidal activity of paromomycin and streptomycin.
|Study Design:||Allocation: Randomized
Endpoint Classification: Pharmacokinetics/Dynamics Study
Primary Purpose: Treatment
|Study Start Date:||November 1994|
|Estimated Study Completion Date:||January 2001|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00004444
|Study Chair:||Thomas Paul Kanyok||University of Illinois at Chicago|