Working… Menu

Study of Pituitary Size and Function in Familial Dwarfism of Sindh

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00004365
Recruitment Status : Completed
First Posted : October 19, 1999
Last Update Posted : June 24, 2005
Northwestern University
Information provided by:
Office of Rare Diseases (ORD)

Brief Summary:

OBJECTIVES: I. Assess pituitary size and anatomic configuration by magnetic resonance imaging (MRI) in 4 affected dwarfs in the province of Sindh, Pakistan.

II. Evaluate ultradian growth hormone (GH) secretory patterns in 4 affected dwarfs.

Condition or disease
Growth Hormone Deficiency

Detailed Description:

PROTOCOL OUTLINE: Pituitary size and anatomy and growth hormone response are evaluated.

All patients undergo MRI of the pituitary fossa on day 1. On day 2, homozygous patients receive a slow infusion of normal saline with blood sampling every 10 minutes.

Layout table for study information
Study Type : Observational
Enrollment : 4 participants
Study Start Date : September 1995
Study Completion Date : February 2000

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   10 Years to 60 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
  • Familial Dwarfism of Sindh
  • Severe short stature but proportionate without dysmorphic features
  • Normal body size and weight at birth
  • Bone age is severely delayed
  • Puberty is somewhat delayed (age 15-16)
  • Fertility present in at least 3 dwarfs

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00004365

Sponsors and Collaborators
National Center for Research Resources (NCRR)
Northwestern University
Layout table for investigator information
Study Chair: Gerhard Baumann Northwestern University
Layout table for additonal information Identifier: NCT00004365    
Other Study ID Numbers: 199/11940
First Posted: October 19, 1999    Key Record Dates
Last Update Posted: June 24, 2005
Last Verified: December 2003
Keywords provided by Office of Rare Diseases (ORD):
endocrine disorders
growth hormone deficiency
rare disease