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Study of Novel Types of Familial Diabetes Insipidus

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00004364
Recruitment Status : Unknown
Verified February 2006 by Office of Rare Diseases (ORD).
Recruitment status was:  Active, not recruiting
First Posted : October 19, 1999
Last Update Posted : February 22, 2006
Northwestern University
Information provided by:
Office of Rare Diseases (ORD)

Brief Summary:


I. Define the phenotype and genotype of previously unrecognized types of familial diabetes insipidus (FDI) in kindreds with atypical or novel forms of FDI.

Condition or disease Intervention/treatment
Diabetes Insipidus Drug: desmopressin

Detailed Description:

PROTOCOL OUTLINE: Participants undergo a series of tests to determine the presence, absence, cause, natural history, clinical status, and mode of inheritance of their type of diabetes insipidus (DI). The studies include measurements of basal fluid intake and urine output, plasma vasopressin during standard fluid deprivation or waterload/saline infusion tests, and changes in water balance during a therapeutic trial of DDAVP. If clinically indicated, echocardiograms and assays of plasma catecholes and renin are also completed.

Linkage analysis is performed for all participants; kindreds with the Marfan-like syndrome are also studied for the fibrillin-1 genotype.

Participants determined to have DI are treated with desmopressin for 2 days.

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Study Type : Observational
Enrollment : 5 participants
Study Start Date : December 1995

Resource links provided by the National Library of Medicine

Information from the National Library of Medicine

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Ages Eligible for Study:   6 Months to 70 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
  • Familial diabetes insipidus (DI) in atypical or novel form, e.g.: Dipsogenic DI Neurohypophyseal DI
  • Affected and unaffected members of kindreds eligible

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00004364

Sponsors and Collaborators
National Center for Research Resources (NCRR)
Northwestern University
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Study Chair: Gary L. Robertson Northwestern University
Layout table for additonal information Identifier: NCT00004364    
Other Study ID Numbers: 199/11939
First Posted: October 19, 1999    Key Record Dates
Last Update Posted: February 22, 2006
Last Verified: February 2006
Keywords provided by Office of Rare Diseases (ORD):
diabetes insipidus
endocrine disorders
rare disease
Additional relevant MeSH terms:
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Diabetes Insipidus
Endocrine System Diseases
Kidney Diseases
Urologic Diseases
Pituitary Diseases
Deamino Arginine Vasopressin
Antidiuretic Agents
Natriuretic Agents
Physiological Effects of Drugs