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Study of the Relationship Between Calcium Levels and Intact Parathyroid Hormone (iPTH) in Adults With Repaired or Palliated Conotruncal Cardiac Defects

This study has been completed.
Ann & Robert H Lurie Children's Hospital of Chicago
Information provided by:
Office of Rare Diseases (ORD) Identifier:
First received: October 18, 1999
Last updated: June 23, 2005
Last verified: January 2001

OBJECTIVES: I. Identify latent hypoparathyroidism in normocalcemic adult survivors with repaired conotruncal cardiac defects, by evaluating parathyroid gland secretory function after induced hypocalcemia.

II. Determine the relationship of parathyroid hormone secretion to microdeletions in the same region of chromosome 22q11 as found in patients with DiGeorge anomaly.

Condition Intervention
Tetralogy of Fallot
Pulmonary Valve Stenosis
Conotruncal Cardiac Defects
Heart Defects, Congenital
Pulmonary Atresia
Drug: calcium gluconate
Drug: sodium citrate

Study Type: Observational
Study Design: Primary Purpose: Screening

Resource links provided by NLM:

Further study details as provided by Office of Rare Diseases (ORD):

Estimated Enrollment: 150
Study Start Date: July 1995
Detailed Description:


Patients are given sodium citrate over a 2 hour infusion on day 1. Blood is drawn at times -30, -15, 0, and every 10 minutes thereafter during the infusion. On day 2, patients are given calcium gluconate over a 2 hour infusion. Blood is drawn at times -30, -15, 0, and every 10 minutes thereafter during the infusion.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
  • Diagnostically shown repaired or palliated conotruncal cardiac defects, including tetralogy of Fallot with pulmonary stenosis or pulmonary atresia, truncus arteriosus, or interrupted aortic arch type B
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Please refer to this study by its identifier: NCT00004361

Sponsors and Collaborators
National Center for Research Resources (NCRR)
Ann & Robert H Lurie Children's Hospital of Chicago
Study Chair: Craig B. Langman Ann & Robert H Lurie Children's Hospital of Chicago
  More Information Identifier: NCT00004361     History of Changes
Other Study ID Numbers: 199/11936
Study First Received: October 18, 1999
Last Updated: June 23, 2005

Keywords provided by Office of Rare Diseases (ORD):
DiGeorge syndrome
cardiovascular and respiratory diseases
conotruncal cardiac defects
endocrine disorders
genetic diseases and dysmorphic syndromes
pulmonary valve stenosis
rare disease
tetralogy of Fallot

Additional relevant MeSH terms:
Congenital Abnormalities
Heart Defects, Congenital
Tetralogy of Fallot
Pulmonary Atresia
Pulmonary Valve Stenosis
Cardiovascular Abnormalities
Cardiovascular Diseases
Heart Diseases
Parathyroid Diseases
Endocrine System Diseases
Vascular Malformations
Heart Valve Diseases
Ventricular Outflow Obstruction
Calcium, Dietary
Citric Acid
Bone Density Conservation Agents
Physiological Effects of Drugs
Calcium Chelating Agents
Chelating Agents
Sequestering Agents
Molecular Mechanisms of Pharmacological Action processed this record on May 24, 2017