Phase II Pilot Study of Extracorporeal Phototherapy for Epidermolysis Bullosa Acquisita
OBJECTIVES: I. Evaluate immunomodulation with extracorporeal photochemotherapy (ECP) in patients with epidermolysis bullosa acquisita.
II. Investigate the effect of ECP on lymphocyte activity.
|Study Design:||Primary Purpose: Treatment|
|Study Start Date:||February 1996|
PROTOCOL OUTLINE: Oral methoxsalen (8-MOP) is administered 90 minutes prior to leukapheresis. Blood mononuclear cells are exposed to ultraviolet A light for 3 hours, then returned to the patient. The process is repeated on 2 successive days.
Patients are re-treated every 3 to 4 weeks for a total of 6 treatments or until the skin has cleared.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00004359
|Study Chair:||Kenneth B. Gordon||Northwestern University|