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Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic Acidemia

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00004353
First Posted: October 19, 1999
Last Update Posted: July 10, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
University of California, San Diego
Information provided by:
National Center for Research Resources (NCRR)
  Purpose

OBJECTIVES: I. Study the metabolism of pyruvate and related problems in patients with lactic acidemia.

II. Define the nature of the metabolic defect.


Condition
Mitochondrial Myopathy MELAS Syndrome Lactic Acidosis

Study Type: Observational

Resource links provided by NLM:


Further study details as provided by National Center for Research Resources (NCRR):

Estimated Enrollment: 35
Study Start Date: December 1978
Detailed Description:

PROTOCOL OUTLINE: Patients fast for 6 hours. Glucagon IM is administered after the 6 hour fast. Glucose level is measured at 0, 15, 30, 45, 60, and 90 minutes.

In children of sufficient size, alanine and lactic acid should also be measured at each or most of these time points.

Fasting continues for at least 18 hours. Glucagon IM is administered again at end of fast. Glucose level is measured at time 0, 15, 30, 45, 60, and 90 minutes.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

PROTOCOL ENTRY CRITERIA:

  • Diagnostically documented elevation in lactate, pyruvate, and/or alanine levels in lactic acidemia patients
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00004353


Locations
United States, California
University of California San Diego Medical Center
San Diego, California, United States, 92103-8757
Sponsors and Collaborators
National Center for Research Resources (NCRR)
University of California, San Diego
Investigators
Study Chair: Richard H. Haas University of California, San Diego
  More Information

ClinicalTrials.gov Identifier: NCT00004353     History of Changes
Other Study ID Numbers: NCRR-M01RR00827-0071
UCSD-071
First Submitted: October 18, 1999
First Posted: October 19, 1999
Last Update Posted: July 10, 2008
Last Verified: April 2002

Keywords provided by National Center for Research Resources (NCRR):
MELAS syndrome
inborn errors of metabolism
lactic acidosis
mitochondrial myopathy
rare disease

Additional relevant MeSH terms:
MELAS Syndrome
Muscular Diseases
Acidosis
Acidosis, Lactic
Mitochondrial Myopathies
Musculoskeletal Diseases
Neuromuscular Diseases
Nervous System Diseases
Acid-Base Imbalance
Metabolic Diseases
Mitochondrial Diseases
Mitochondrial Encephalomyopathies
Brain Diseases, Metabolic, Inborn
Brain Diseases, Metabolic
Brain Diseases
Central Nervous System Diseases
Cerebral Small Vessel Diseases
Cerebrovascular Disorders
Vascular Diseases
Cardiovascular Diseases
Metabolism, Inborn Errors
Genetic Diseases, Inborn