Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic Acidemia
OBJECTIVES: I. Study the metabolism of pyruvate and related problems in patients with lactic acidemia.
II. Define the nature of the metabolic defect.
|Mitochondrial Myopathy MELAS Syndrome Lactic Acidosis|
|Study Start Date:||December 1978|
PROTOCOL OUTLINE: Patients fast for 6 hours. Glucagon IM is administered after the 6 hour fast. Glucose level is measured at 0, 15, 30, 45, 60, and 90 minutes.
In children of sufficient size, alanine and lactic acid should also be measured at each or most of these time points.
Fasting continues for at least 18 hours. Glucagon IM is administered again at end of fast. Glucose level is measured at time 0, 15, 30, 45, 60, and 90 minutes.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00004353
|United States, California|
|University of California San Diego Medical Center|
|San Diego, California, United States, 92103-8757|
|Study Chair:||Richard H. Haas||University of California, San Diego|