Phase II Study of Cholesterol- and Cholestanol-Free Diet, Lovastatin, and Chenodeoxycholic Acid for Cerebrotendinous Xanthomatosis
Recruitment status was: Recruiting
OBJECTIVES: I. Assess the biosynthesis of cholesterol and cholestanol, and measure the turnover of individual sterols and bile acids in patients with cerebrotendinous xanthomatosis before and after a cholesterol- and cholestanol-free diet.
II. Assess the biosynthesis of cholesterol and cholestanol, and measure the turnover of individual sterols and bile acids in these patients before and after lovastatin and chenodeoxycholic acid.
Drug: chenodeoxycholic acid
|Study Design:||Primary Purpose: Treatment|
|Official Title:||Effects of Diet and Medication in Patients With Cerebrotendinous Xanthomatosis (CTX)|
|Study Start Date:||January 1996|
PROTOCOL OUTLINE: Following a 2-week baseline assessment, patients participate in a feeding study for up to 3 weeks. The diet is free of cholesterol and cholestanol.
For the next 4 weeks, patients return to their typical diet and are medicated with daily lovastatin and chenodeoxycholic acid.
The feeding study is repeated for an additional 3 weeks, with the patient taking either lovastatin or chenodeoxycholic acid.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00004346
|United States, Oregon|
|Oregon Health and Science University|
|Portland, Oregon, United States, 97239-3098|
|Study Chair:||William Connor||Oregon Health and Science University|