Purification of Testis-Stimulating Factor in Precocious Puberty

This study has been completed.
Oregon Health and Science University
Information provided by:
Office of Rare Diseases (ORD)
ClinicalTrials.gov Identifier:
First received: October 18, 1999
Last updated: June 23, 2005
Last verified: February 2000


Purify and characterize a testis-stimulating factor in the blood of adult volunteers who had precocious puberty as boys.

Condition Intervention
Precocious Puberty
Drug: leuprolide
Drug: testosterone

Study Type: Observational
Study Design: Primary Purpose: Screening

Resource links provided by NLM:

Further study details as provided by Office of Rare Diseases (ORD):

Estimated Enrollment: 4
Study Start Date: January 1997
Detailed Description:

PROTOCOL OUTLINE: Subjects are treated for 2 months with depot injections of leuprolide acetate every 4 weeks and testosterone replacement every 2 weeks. Hormone levels are tested every other week.

If luteinizing hormone and follicular-stimulating hormone levels are at or below detection on day 56, blood is drawn for a testis-stimulating factor bioassay and subsequent factor purification and characterization.

Volunteers are asked to repeat this 2-month procedure no more than 2 times every 12 months.


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No


Adult men diagnosed with precocious puberty (familial testotoxicosis) as boys

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Please refer to this study by its ClinicalTrials.gov identifier: NCT00004344

Sponsors and Collaborators
National Center for Research Resources (NCRR)
Oregon Health and Science University
Study Chair: Barry Albertson Oregon Health and Science University
  More Information

ClinicalTrials.gov Identifier: NCT00004344     History of Changes
Other Study ID Numbers: 199/11903  OHSU-3328 
Study First Received: October 18, 1999
Last Updated: June 23, 2005
Health Authority: United States: Federal Government

Keywords provided by Office of Rare Diseases (ORD):
endocrine disorders
precocious puberty
rare disease

Additional relevant MeSH terms:
Puberty, Precocious
Endocrine System Diseases
Gonadal Disorders

ClinicalTrials.gov processed this record on May 26, 2016