Purification of Testis-Stimulating Factor in Precocious Puberty
Purify and characterize a testis-stimulating factor in the blood of adult volunteers who had precocious puberty as boys.
|Study Design:||Primary Purpose: Screening|
|Study Start Date:||January 1997|
PROTOCOL OUTLINE: Subjects are treated for 2 months with depot injections of leuprolide acetate every 4 weeks and testosterone replacement every 2 weeks. Hormone levels are tested every other week.
If luteinizing hormone and follicular-stimulating hormone levels are at or below detection on day 56, blood is drawn for a testis-stimulating factor bioassay and subsequent factor purification and characterization.
Volunteers are asked to repeat this 2-month procedure no more than 2 times every 12 months.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00004344
|Study Chair:||Barry Albertson||Oregon Health and Science University|