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International Registry for Severe Chronic Neutropenia

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ClinicalTrials.gov Identifier: NCT00004342
Recruitment Status : Unknown
Verified December 2003 by National Center for Research Resources (NCRR).
Recruitment status was:  Recruiting
First Posted : October 19, 1999
Last Update Posted : June 24, 2005
University of Washington
Information provided by:
National Center for Research Resources (NCRR)

Brief Summary:

OBJECTIVES: I. Document the clinical course of severe chronic neutropenia (SCN).

II. Monitor and assess long term safety of primary treatment in SCN patients in the United States, Canada, Europe, and Australia.

III. Study the incidence and outcome of adverse events such as osteoporosis, splenomegaly, cytogenetic abnormalities, myelodysplastic syndrome, and leukemia.

IV. Evaluate growth and development and hematologic parameters. V. Monitor for clinically significant changes in primary treatment response over time.

VI. Establish a physician network to increase the understanding of SCN. VII. Establish a demographic database to allow for future research.

Condition or disease

Detailed Description:


Patients are treated by the referring physician as medically indicated. Clinical data are collected at baseline and then every 6 months.

Study Type : Observational
Estimated Enrollment : 1000 participants
Observational Model: Natural History
Study Start Date : June 1994

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Ages Eligible for Study:   3 Months and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No


--Disease Characteristics-- Severe chronic neutropenia (SCN), i.e.: Absolute neutrophil count less than 500/mm3 on 3 occasions within the last 3 months (less than 200/mm3 for cyclic neutropenia) Bone marrow aspirate consistent with SCN History of infection No drug induced neutropenia No myelodysplastic syndrome No aplastic anemia No thrombocytopenia or anemia unless due to Shwachman-Diamond syndrome or glycogen storage disease type IB Prior enrollment on Amgen SCN trials eligible Bone marrow aspiration within 1 year required Cytogenetic evaluation strongly suggested --Prior/Concurrent Therapy-- At least 5 years since prior chemotherapy --Patient Characteristics-- No rheumatoid arthritis No systemic lupus erythematosus No HIV seropositivity

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00004342

United States, Michigan
Women's Hospital Recruiting
Ann Arbor, Michigan, United States, 48109-0266
Contact: Laurence A. Boxer    734-764-7127      
United States, New Jersey
St. Barnabas Medical Center Recruiting
Livingston, New Jersey, United States, 07039
Contact: Donna Mura    973-322-8076    dmura@sbhcs.com   
United States, Washington
University of Washington School of Medicine Recruiting
Seattle, Washington, United States, 98195
Contact: David Chandler Dale    206-543-7215      
Australia, Victoria
Central Highlands Oncology Program Recruiting
Ballarat, Victoria, Australia, 3350
Contact: George Kannourakis    61-353-334811      
Canada, Manitoba
CancerCare Manitoba Recruiting
Winnipeg, Manitoba, Canada, R3E 0V9
Contact: Bonnie Paula Cham    204-787-4147      
Canada, Ontario
Hospital for Sick Children Recruiting
Toronto, Ontario, Canada, M5G 1X8
Contact: Melvin H. Freedman    416-813-6152      
Medizinische Hochschule Hannover Recruiting
Hannover, Germany, D-30625
Contact: Karl Welte    0511-532-6710      
Istituto Giannina Gaslini Recruiting
Genova, Italy, 16148
Contact: Pier G. Mori    10-5636-331      
United Kingdom
St. James's Hospital Recruiting
Leeds, England, United Kingdom, LS9 7TF
Contact: Sally Kinsey    113 243 31 44      
Sponsors and Collaborators
National Center for Research Resources (NCRR)
University of Washington
Study Chair: David Chandler Dale University of Washington

ClinicalTrials.gov Identifier: NCT00004342     History of Changes
Other Study ID Numbers: 199/11901
First Posted: October 19, 1999    Key Record Dates
Last Update Posted: June 24, 2005
Last Verified: December 2003

Keywords provided by National Center for Research Resources (NCRR):
chronic neutropenia
disease-related problem/condition
hematologic disorders
rare disease
severe chronic neutropenia

Additional relevant MeSH terms:
Leukocyte Disorders
Hematologic Diseases