Hippocampal Complex Volume and Memory Dysfunction in Cushing's Syndrome
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|ClinicalTrials.gov Identifier: NCT00004326|
Recruitment Status : Completed
First Posted : October 19, 1999
Last Update Posted : June 24, 2005
OBJECTIVES: I. Evaluate whether chronic hypercortisolemia is specifically toxic to hippocampal cells and causes structural reduction of hippocampal volume in patients with Cushing's syndrome.
II. Determine whether reduced hippocampal volume is associated with specific memory dysfunction.
III. Examine the relationships of adrenal androgen to hippocampal volume and memory dysfunction.
IV. Examine the reversibility of hippocampal structural changes and cognitive dysfunction after cortisol levels are normalized.
|Condition or disease|
PROTOCOL OUTLINE: Patients undergo a psychiatric evaluation for mood and cognition during confirmation of diagnosis. Neuropsychologic exams include pencil and paper test and a cognitive assessment.
Endocrine studies include dexamethasone and corticotropin-releasing hormone stimulation tests. The hippocampal complex volume is assessed with coronal magnetic resonance imaging.
There is a follow-up 1 year after the initiation of treatment.
|Study Type :||Observational|
|Estimated Enrollment :||12 participants|
|Study Start Date :||August 1994|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00004326
|United States, Michigan|
|University of Michigan Health Systems|
|Ann Arbor, Michigan, United States, 48109|
|Study Chair:||Monica N. Starkman||University of Michigan|