Phase II Randomized Study of Intravenous Versus Oral Clomipramine in Patients With Obsessive Compulsive Disorder
Recruitment status was Active, not recruiting
I. Evaluate the efficacy of intravenous versus oral pulse loading of clomipramine (CMI) followed by a 12-week course of maintenance therapy in patients with obsessive compulsive disorder.
|Study Design:||Allocation: Randomized
Primary Purpose: Treatment
|Study Start Date:||October 1999|
PROTOCOL OUTLINE: This is a randomized, double blind, multicenter study. Patients are stratified by participating institution. Patients are randomized into one of two treatment arms.
Arm I: Patients receive a pulse loading dose of clomipramine (CMI) IV and an oral placebo on days 1 and 2.
Arm II: Patients receive an oral pulse loading dose of CMI and an IV placebo on days 1 and 2.
Patients receive maintenance therapy with daily oral CMI for 12 weeks beginning 4 days after pulse loading.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00004310
|United States, California|
|Stanford University Medical Center|
|Stanford, California, United States, 94305-5408|
|United States, Ohio|
|University of Cincinnati Medical Center|
|Cincinnati, Ohio, United States, 45267-0562|
|Study Chair:||Lorrin Koran||Stanford University|