Multicenter Study of Nontuberculous Mycobacteria in Cystic Fibrosis Patients
OBJECTIVES: I. Determine the prevalence of nontuberculous mycobacteria in sputum cultures from patients with cystic fibrosis.
II. Compare the clinical course of patients with negative versus positive cultures.
Atypical Mycobacterium Infection
|Study Design:||Primary Purpose: Screening
Time Perspective: Longitudinal
|Study Start Date:||September 1995|
PROTOCOL OUTLINE: Participants are screened for nontuberculous mycobacteria (NTM) with 3 sputum acid-fast bacilli smears and mycobacterial cultures, with speciation of positive cultures, collected over 1 year. Demographic data, diagnostic criteria, clinical measurements, and other respiratory pathogen data are collected using the Cystic Fibrosis Foundation Patient Registry Questionnaire.
NTM-positive patients (cases) matched with NTM-negative controls identified in screening are followed every 3 months for 15 months. Cases are evaluated for NTM burden during the first 3 months.
Appropriate therapy is offered to consistently NTM-positive cases. Lung transplant recipients are removed from study.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00004296
|Study Chair:||Ken Olivier||University of North Carolina|