Effect of Estrogen on Mental and Social Functioning in Girls With Turner's Syndrome
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|ClinicalTrials.gov Identifier: NCT00004274|
Recruitment Status : Completed
First Posted : October 19, 1999
Last Update Posted : June 24, 2005
RATIONALE: Turner's syndrome is a disease in which females are missing all or part of one X chromosome and do not produce estrogen. Giving estrogen is standard treatment for girls who have Turner's syndrome. Estrogen may be effective treatment for mental and social functioning problems experienced by girls with Turner's syndrome.
PURPOSE: Clinical trial to study the effectiveness of long term estrogen therapy on mental and social functioning in girls who have Turner's syndrome.
|Condition or disease||Intervention/treatment||Phase|
|Turner's Syndrome||Drug: Estrogen||Not Applicable|
PROTOCOL OUTLINE: Participants are evaluated for cognitive and social function at entry and 4 years following entry. Assessments include the Wechsler Intelligence Scale for Children-Revised, a child behavior checklist, the Children's Self-Concept Scale, and visual-spatial, visual-motor, attention, memory, language, and facial recognition tasks.
Patients (and parents) undergo X-chromosome analysis; brain magnetic imaging is optional.
Controls are matched using school selection and telephone interviews.
A study duration of 12 years is estimated.
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||260 participants|
|Official Title:||Controlled Study of Estrogen Effects on Cognitive and Social Function in Girls With Turner's Syndrome|
|Study Start Date :||February 1990|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00004274
|United States, Pennsylvania|
|Jefferson Medical College of Thomas Jefferson University|
|Philadelphia, Pennsylvania, United States, 19107-5083|
|Study Chair:||Judith Levine Ross||Jefferson Medical College of Thomas Jefferson University|