Effect of Estrogen on Mental and Social Functioning in Girls With Turner's Syndrome

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00004274
Recruitment Status : Completed
First Posted : October 19, 1999
Last Update Posted : June 24, 2005
Jefferson Medical College of Thomas Jefferson University
Information provided by:
Office of Rare Diseases (ORD)

Brief Summary:

RATIONALE: Turner's syndrome is a disease in which females are missing all or part of one X chromosome and do not produce estrogen. Giving estrogen is standard treatment for girls who have Turner's syndrome. Estrogen may be effective treatment for mental and social functioning problems experienced by girls with Turner's syndrome.

PURPOSE: Clinical trial to study the effectiveness of long term estrogen therapy on mental and social functioning in girls who have Turner's syndrome.

Condition or disease Intervention/treatment Phase
Turner's Syndrome Drug: Estrogen Not Applicable

Detailed Description:

PROTOCOL OUTLINE: Participants are evaluated for cognitive and social function at entry and 4 years following entry. Assessments include the Wechsler Intelligence Scale for Children-Revised, a child behavior checklist, the Children's Self-Concept Scale, and visual-spatial, visual-motor, attention, memory, language, and facial recognition tasks.

Patients (and parents) undergo X-chromosome analysis; brain magnetic imaging is optional.

Controls are matched using school selection and telephone interviews.

A study duration of 12 years is estimated.

Study Type : Interventional  (Clinical Trial)
Enrollment : 260 participants
Primary Purpose: Treatment
Official Title: Controlled Study of Estrogen Effects on Cognitive and Social Function in Girls With Turner's Syndrome
Study Start Date : February 1990

Information from the National Library of Medicine

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Ages Eligible for Study:   8 Years to 12 Years   (Child)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes


  • Girls aged 8 and 12 years with Turner's syndrome-compatible karyotype
  • Age-matched girls without Turner's syndrome entered as controls
  • Concurrent registration on Thomas Jefferson University growth study required of subjects with Turner's syndrome

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00004274

United States, Pennsylvania
Jefferson Medical College of Thomas Jefferson University
Philadelphia, Pennsylvania, United States, 19107-5083
Sponsors and Collaborators
National Institute of Neurological Disorders and Stroke (NINDS)
Jefferson Medical College of Thomas Jefferson University
Study Chair: Judith Levine Ross Jefferson Medical College of Thomas Jefferson University Identifier: NCT00004274     History of Changes
Other Study ID Numbers: 199/11680
First Posted: October 19, 1999    Key Record Dates
Last Update Posted: June 24, 2005
Last Verified: October 2003

Keywords provided by Office of Rare Diseases (ORD):
Turner's syndrome
genetic diseases and dysmorphic syndromes
rare disease

Additional relevant MeSH terms:
Turner Syndrome
Gonadal Dysgenesis
Primary Ovarian Insufficiency
Pathologic Processes
Disorders of Sex Development
Urogenital Abnormalities
Sex Chromosome Disorders of Sex Development
Heart Defects, Congenital
Cardiovascular Abnormalities
Cardiovascular Diseases
Heart Diseases
Congenital Abnormalities
Sex Chromosome Disorders
Chromosome Disorders
Genetic Diseases, Inborn
Gonadal Disorders
Endocrine System Diseases
Ovarian Diseases
Adnexal Diseases
Genital Diseases, Female
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs