Effect of Estrogen on Mental and Social Functioning in Girls With Turner's Syndrome
RATIONALE: Turner's syndrome is a disease in which females are missing all or part of one X chromosome and do not produce estrogen. Giving estrogen is standard treatment for girls who have Turner's syndrome. Estrogen may be effective treatment for mental and social functioning problems experienced by girls with Turner's syndrome.
PURPOSE: Clinical trial to study the effectiveness of long term estrogen therapy on mental and social functioning in girls who have Turner's syndrome.
|Study Design:||Primary Purpose: Treatment|
|Official Title:||Controlled Study of Estrogen Effects on Cognitive and Social Function in Girls With Turner's Syndrome|
|Study Start Date:||February 1990|
PROTOCOL OUTLINE: Participants are evaluated for cognitive and social function at entry and 4 years following entry. Assessments include the Wechsler Intelligence Scale for Children-Revised, a child behavior checklist, the Children's Self-Concept Scale, and visual-spatial, visual-motor, attention, memory, language, and facial recognition tasks.
Patients (and parents) undergo X-chromosome analysis; brain magnetic imaging is optional.
Controls are matched using school selection and telephone interviews.
A study duration of 12 years is estimated.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00004274
|United States, Pennsylvania|
|Jefferson Medical College of Thomas Jefferson University|
|Philadelphia, Pennsylvania, United States, 19107-5083|
|Study Chair:||Judith Levine Ross||Jefferson Medical College of Thomas Jefferson University|