Hyperthermia Plus Radiation Therapy in Treating Patients With Nonmetastatic Advanced Prostate Cancer
RATIONALE: Hyperthermia therapy may kill prostate cancer cells by heating them to several degrees above body temperature. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining hyperthermia with radiation therapy may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of hyperthermia plus radiation therapy in treating patients who have nonmetastatic advanced prostate cancer.
Procedure: hyperthermia treatment
Radiation: radiation therapy
|Study Design:||Primary Purpose: Treatment|
|Official Title:||A Phase II Trial of Hyperthermia and Radiotherapy for Locally Advanced Adenocarcinoma of the Prostate|
|Study Start Date:||April 1997|
- Evaluate the efficacy of hyperthermia and radiation therapy in patients with locally advanced prostate cancer.
- Evaluate the acute and long term toxicities of these therapies in this patient population.
OUTLINE: Patients are treated with external beam irradiation 5 days a week for a total of approximately 7 weeks. Hyperthermia treatment is given twice in the first 4 weeks of radiation therapy, preferably early in the course of radiation. Hyperthermia treatments are only given once a week. A transrectal ultrasound applicator is used to deliver the hyperthermia treatment.
Patients are followed every three months for 2 years, and every 6 months thereafter.
PROJECTED ACCRUAL: Approximately 65 patients will be accrued over 2 years.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00003045
|United States, Massachusetts|
|Dana-Farber Cancer Institute|
|Boston, Massachusetts, United States, 02115|
|Joint Center for Radiation Therapy|
|Boston, Massachusetts, United States, 02215|
|Study Chair:||Mark Hurwitz, MD||Dana-Farber Cancer Institute|