Combination Chemotherapy Plus Surgery and Radiation Therapy in Treating Patients With Ewing's Sarcoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining more than one drug with surgery and radiation therapy may kill more tumor cells. It is not yet known which combination chemotherapy regimen is most effective in treating patients with Ewing's sarcoma.
PURPOSE: Randomized phase III trial to compare various combination chemotherapy regimens plus surgery and radiation therapy in treating patients who have Ewing's sarcoma.
Drug: doxorubicin hydrochloride
Drug: vincristine sulfate
Procedure: conventional surgery
Radiation: low-LET cobalt-60 gamma ray therapy
Radiation: low-LET photon therapy
|Study Design:||Primary Purpose: Treatment|
|Official Title:||EUROPEAN INTERGROUP COOPERATIVE EWING'S SARCOMA STUDY [EICESS 92]|
|Study Start Date:||July 1992|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00002516
|Royal Victoria Infirmary|
|Newcastle-upon-Tyne, England, United Kingdom, NE1 4LP|
|Study Chair:||Heribert F. Juergens, MD||University Hospital Muenster|
|Study Chair:||Alan W. Craft, MD||Newcastle-upon-Tyne Hospitals NHS Trust|