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Trial record 46 of 280 for:    Genetic Diseases, Inborn AND Genome

Microarray Analysis for Human Genetic Disease

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00001898
Recruitment Status : Completed
First Posted : November 4, 1999
Last Update Posted : July 2, 2017
Information provided by:
National Institutes of Health Clinical Center (CC)

Brief Summary:

This study will look at genetic changes which occur in the development of male and female breast cancer and other cancer. It will use a new technology called DNA microarray hybridization that looks at a wide array of genes to identify disease-associated patterns in the human genome (complete set of human genes). Numerous studies have linked particular genes to a given disease, but there is very little information on patterns of gene expression (production of proteins from genetic coding) in the entire human genome.

Pinpointing genetic abnormalities in disease may help classify different forms of cancer and perhaps lead to new avenues of treatment or prevention. A primary goal of this study will be to create a database of gene expression for human cancers and other disorders that will provide the basis for finding genetic abnormalities in disease.

Tumors specimens used in this study will be taken from tissues biopsied from patients with breast, colon cancer, sarcomas or melanoma as part of their routine care. Patients in the study will be among those receiving care at the: Department of Oncology, University Hospital, University of Lund, Sweden (breast cancer); Department of Medicine, University of Michigan, Ann Arbor, Michigan (breast cancer); Surgery Branch, National Cancer Institute, Bethesda, Maryland (melanoma), Johns Hopkins Univ. (colon cancer), Memorial Sloan Kettering (sarcoma).

Patients in the study will have a family history taken and will complete a questionnaire. Some patients will be asked to have a blood test. Breast cancer patients will have a mammogram if one has not been done within the last year.

Condition or disease
Breast Neoplasm Hereditary Neoplastic Syndrome Melanoma Ovarian Neoplasm

Detailed Description:
The purpose of our study is to make use of a novel technology that the Cancer Genetics Branch of the NHGRI has been a leader in developing. This technology for genome-wide expression analysis, DNA microarray hybridization, is the focus of our protocol. We will access tissue banks collected by our collaborators that contain excess tissues obtained during routine clinical care. Specimens will be processed for large-scale gene expression analysis and DNA copy number determination using DNA microarrays. The development and analysis of this gene expression and gene copy number database are the primary purpose of this study. Currently available and new bioinformatics tools will be applied to the data for the characterization of disease subsets (e.g., early vs. advanced stage cancer) as well as to mine the data for specific genes which are linked to given disease states.

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Study Type : Observational
Enrollment : 1500 participants
Official Title: Microarray Analysis for Human Genetic Disease
Study Start Date : June 29, 1999
Study Completion Date : May 20, 2008

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
  • Clinical inclusion/exclusion criteria will be dependent upon the collaborating Institutions' requirements.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00001898

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United States, Arizona
Arizona Cancer Center
Tucson, Arizona, United States, 85724
United States, Maryland
Johns Hopkins University
Baltimore, Maryland, United States, 21205
United States, Michigan
University of Michigan
Ann Arbor, Michigan, United States, 48109-0624
United States, New York
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10021
United States, Texas
MD Anderson Cancer Center
Houston, Texas, United States, 77030-4096
Helsinki University Central Hospital
Helsinki, Finland
University of Iceland
Reykjavik, Iceland
University of Lund
Lund, Sweden
Sponsors and Collaborators
National Human Genome Research Institute (NHGRI)

Layout table for additonal information Identifier: NCT00001898     History of Changes
Other Study ID Numbers: 990130
First Posted: November 4, 1999    Key Record Dates
Last Update Posted: July 2, 2017
Last Verified: May 20, 2008
Keywords provided by National Institutes of Health Clinical Center (CC):
Breast Cancer
Gene Expression
DNA Chip Technology
Expressed Sequence Tags
Additional relevant MeSH terms:
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Genetic Diseases, Inborn
Breast Diseases
Skin Diseases
Ovarian Diseases
Adnexal Diseases
Genital Diseases, Female
Endocrine System Diseases
Gonadal Disorders
Breast Neoplasms
Ovarian Neoplasms
Neoplastic Syndromes, Hereditary
Neuroendocrine Tumors
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms, Nerve Tissue
Nevi and Melanomas
Neoplasms by Site
Endocrine Gland Neoplasms
Genital Neoplasms, Female
Urogenital Neoplasms