Magnetic Stimulation of the Human Nervous System

This study has been completed.

Sponsor:

ClinicalTrials.gov Identifier:

NCT00001780

First Posted: November 4, 1999

Last Update Posted: March 4, 2008

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.

Information provided by:

National Institutes of Health Clinical Center (CC)

Purpose

Transcranial Magnetic Stimulation (TMS) is a non-invasive technique to gather information about brain function. It is very useful when studying the areas of the brain related to motor activity (motor cortex, corticospinal tract, spinal cord and nerve roots). The procedure is conducted by transmitting a magnetic signal into the brain to stimulate an area of the body. Electrodes (small pieces of metal taped to areas of the body) are used in order to measure electrical activity. A magnetic signal is sent from a metal instrument held close to the patient's head, to an area of the brain responsible for motor activity of a certain area of the body. The electrodes pick up and record the electrical activity in the muscles.

This study will employ the use of TMS to diagnose neurological disorders that affect the motor cortex or the corticospinal tract. Normal subjects are sometimes studied to investigate normal activity of the nervous system and to train doctors in clinical neurophysiology and electrodiagnostic medicine at the National Institutes of Health (NIH).

Condition
Demyelinating Disease Healthy Lysosomal Storage Disease Motor Neuron Disease Movement Disorder


Study Type:	Observational
Official Title:	Stimulation of the Human Central and Peripheral Nervous System With a Magnetic Stimulator

Resource links provided by NLM:

Genetics Home Reference related topics: Schindler disease

Genetic and Rare Diseases Information Center resources: Leukodystrophy

U.S. FDA Resources

Further study details as provided by National Institutes of Health Clinical Center (CC):


Estimated Enrollment:	450
Study Start Date:	February 1998
Estimated Study Completion Date:	November 2005

Detailed Description:

This protocol outlines the use of magnetic stimulation as a diagnostic tool in patients with suspected dysfunction of central motor pathways or nerve roots and as a tool to localize and characterize suspected corticospinal abnormalities in neurologic disorders and systemic disorders with neurological manifestations. The protocol is intended for clinical use.

Transcranial magnetic stimulation has been used for diagnosis of neurologic disorders since 1987. The principles of magnetic stimulation and its use for diagnosis are described in current textbooks of clinical neurophysiology as a routine procedure and should be included in the training program for fellows in clinical neurophysiology and electrodiagnostic medicine at NIH.

The magnetic stimuli are to be given as single or paired pulses at repetition rates less than 1 per second.

Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:	Child, Adult, Senior
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	Yes

Criteria

INCLUSION CRITERIA:

Adult patients with weakness or motor dysfunction.

Children and adolescents with corticospinal tract signs.

Normal volunteers, adults.

Normal volunteers, children aged 4-17.

EXCLUSION CRITERIA:

Pregnant women.

Subjects with implanted devices: pacemakers, medication pumps or defibrillators.

Subjects with metal in the cranium except the mouth.

Subjects with intracardiac lines.

Normal subjects with history of seizures.

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001780

Locations


United States, Maryland
National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States, 20892

Sponsors and Collaborators

National Institute of Neurological Disorders and Stroke (NINDS)

More Information

Publications:

Eisen AA, Shtybel W. AAEM minimonograph #35: Clinical experience with transcranial magnetic stimulation. Muscle Nerve. 1990 Nov;13(11):995-1011.

Wassermann EM, Samii A, Mercuri B, Ikoma K, Oddo D, Grill SE, Hallett M. Responses to paired transcranial magnetic stimuli in resting, active, and recently activated muscles. Exp Brain Res. 1996 Apr;109(1):158-63.

Müller K, Hömberg V, Lenard HG. Magnetic stimulation of motor cortex and nerve roots in children. Maturation of cortico-motoneuronal projections. Electroencephalogr Clin Neurophysiol. 1991 Feb;81(1):63-70.


ClinicalTrials.gov Identifier:	NCT00001780 History of Changes
Other Study ID Numbers:	980065 98-N-0065
First Submitted:	November 3, 1999
First Posted:	November 4, 1999
Last Update Posted:	March 4, 2008
Last Verified:	November 2005

Keywords provided by National Institutes of Health Clinical Center (CC):


Myelopathy Demyelination Leukodystrophy	Motor Neuron Disease Movement Disorders Normal Volunteer

Additional relevant MeSH terms:


Movement Disorders Motor Neuron Disease Lysosomal Storage Diseases Demyelinating Diseases Central Nervous System Diseases Nervous System Diseases	Neurodegenerative Diseases Neuromuscular Diseases Genetic Diseases, Inborn Metabolic Diseases Metabolism, Inborn Errors

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