The Classification and Cause of Leukodystrophies of Unknown Cause
Leukodystrophy is a disease of the white matter of the brain. White matter is the portion of the brain responsible for conducting electrical impulses from one area of the brain to the other. Insulating cells called myelin cover the brain and nerve cells in the white matter. If myelin becomes damaged electrical information cannot be transferred properly.
Many patients suffering from leukodystrophies do not fit the description of any of the defined types of leukodystrophies and are therefore considered to have a leukodystrophy of unknown cause.
The purpose of this study is to define groups of patients with leukodystrophies and to work toward finding the cause of the disorders. In order to do this, researchers will analyze patients with leukodystrophies of unknown causes. Patients will undergo clinical, neurophysiologic, biochemical, and genetic examinations and tests.
Researchers believe that by studying these patients and their disorders they will be able to better understand the causes of myelin destruction, and eventually lead to effective treatments for these disorders.
|Lysosomal Storage Disease|
|Official Title:||The Nosology and Etiology of Leukodystrophies of Unknown Cause|
|Study Start Date:||September 9, 1997|
|Estimated Study Completion Date:||December 15, 2008|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00001671
|United States, California|
|University of California, San Francisco|
|San Francisco, California, United States, 94143|
|United States, District of Columbia|
|Childrens National Medical Center|
|Washington, D.C., District of Columbia, United States|
|Institut National de la Sante' et de la Recherche Medicale|
|Clermont-Ferrand, Cedex, France, 63001|
|Tel Aviv University|
|Tel Aviv, Israel|
|Academiseh Ziuekenhuis Vrije Universiteit|