The Classification and Cause of Leukodystrophies of Unknown Cause
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00001671|
Recruitment Status : Completed
First Posted : November 4, 1999
Last Update Posted : July 2, 2017
Leukodystrophy is a disease of the white matter of the brain. White matter is the portion of the brain responsible for conducting electrical impulses from one area of the brain to the other. Insulating cells called myelin cover the brain and nerve cells in the white matter. If myelin becomes damaged electrical information cannot be transferred properly.
Many patients suffering from leukodystrophies do not fit the description of any of the defined types of leukodystrophies and are therefore considered to have a leukodystrophy of unknown cause.
The purpose of this study is to define groups of patients with leukodystrophies and to work toward finding the cause of the disorders. In order to do this, researchers will analyze patients with leukodystrophies of unknown causes. Patients will undergo clinical, neurophysiologic, biochemical, and genetic examinations and tests.
Researchers believe that by studying these patients and their disorders they will be able to better understand the causes of myelin destruction, and eventually lead to effective treatments for these disorders.
|Condition or disease|
|Lysosomal Storage Disease|
|Study Type :||Observational|
|Enrollment :||400 participants|
|Official Title:||The Nosology and Etiology of Leukodystrophies of Unknown Cause|
|Study Start Date :||September 9, 1997|
|Study Completion Date :||December 15, 2008|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001671
|United States, California|
|University of California, San Francisco|
|San Francisco, California, United States, 94143|
|United States, District of Columbia|
|Childrens National Medical Center|
|Washington, D.C., District of Columbia, United States|
|Institut National de la Sante' et de la Recherche Medicale|
|Clermont-Ferrand, Cedex, France, 63001|
|Tel Aviv University|
|Tel Aviv, Israel|
|Academiseh Ziuekenhuis Vrije Universiteit|