Genetic Aspects of Neurologic and Psychiatric Disorders
The purpose of this study is to improve the understanding of the genetic causes of specific neurologic and psychiatric disorders. The study will focus on conditions of mental retardation, childhood onset schizophrenia, attention deficit hyperactivity disorder (ADHD), atypical psychosis of childhood, and bipolar affective disorder.
The study addresses the belief that there may be several genes contributing to the illness. Researchers intend to use several molecular genetic techniques in order to identify the areas of chromosomes containing genes responsible for the development of these disorders.
Patients will be selected to participate in this study based on an early age of onset of their condition as well as the severity of the illness and the frequency of the illness among family members. Researchers will collect DNA samples from patients as well as affected and unaffected family members of each patient. The DNA samples collected will be analyzed for a variety of genetic abnormalities including; triplet repeat expansions, chromosome rearrangements, and polymorphisms.
|Attention Deficit Disorder With Hyperactivity Bipolar Disorder Mental Disorder Diagnosed in Childhood Mental Retardation Schizophrenia|
|Official Title:||Genetic Aspects of Neurologic and Psychiatric Disorders|
|Study Start Date:||April 1996|
|Estimated Study Completion Date:||March 2004|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00001544
|United States, Maryland|
|National Institute of Mental Health (NIMH)|
|Bethesda, Maryland, United States, 20892|