Genetic Factors and Interrelationships for Cancer Risk-Related Behaviors and Complex Traits

Study Description

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Brief Summary:

We propose to conduct a multifactorial genetic study of cancer risk-related behaviors and other complex human characteristics. The main areas of interest are tobacco smoking, excess alcohol consumption, psychological traits, and HIV/AIDS susceptibility and progression. The subjects will be adult male and female probands who display one or more of the phenotypes of interest together with their brothers, sisters and parents. Information on tobacco and alcohol use, psychological and personality traits, sexual behavior, HIV status and progression, and other characteristics with possible genetic components will be obtained through structured interviews and questionnaires. DNA will be prepared from blood samples and typed for a series of candidate genes chosen for function and for random polymorphic markers. By correlating the genotypic and phenotypic information, we hope to identify individual loci that interactively contribute to many different aspects of human health and disease.

Condition or disease
Acquired Immunodeficiency Syndrome; Alcoholism; HIV Infection; Neoplasm; Smoking

Detailed Description:

We propose to conduct a multifactorial genetic study of cancer risk-related behaviors and other complex human characteristics. The main areas of interest are tobacco smoking, excess alcohol consumption, psychological traits, and HIV/AIDS susceptibility and progression. The subjects will be adult male and female probands who display one or more of the phenotypes of interest together with their brothers, sisters and parents. Information on tobacco and alcohol use, psychological and personality traits, sexual behavior, HIV status and progression, and other characteristics with possible genetic components will be obtained through structured interviews and questionnaires. DNA will be prepared from blood samples and typed for a series of candidate genes chosen for function and for random polymorphic markers. By correlating the genotypic and phenotypic information, we hope to identify individual loci that interactively contribute to many different aspects of human health and disease.

Study Design

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Study Type :	Observational
Enrollment :	4500 participants
Official Title:	Genetic Factors and Interrelationships for Cancer Risk-Related Behaviors and Complex Traits
Study Start Date :	April 1996
Study Completion Date :	July 2004

Groups and Cohorts

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Outcome Measures

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Eligibility Criteria

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Ages Eligible for Study:	Child, Adult, Older Adult
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	Yes

Criteria

INCLUSION CRITERIA:

The basic requirement for entry in the study will be the presence of any individual smoker who is willing to complete the evaluation process and donate a blood sample.

Additional siblings will be encouraged but not required to participate.

Probands will be recruited through smoking cessation programs at the National Naval Medical Center.

Attendees at programs offered by the Health Promotions Department and the Military Family Health Center will be invited to participate in this study.

EXCLUSION CRITERIA:

All subjects will be adults (greater than 18 years).

There will be no exclusions based on sex, ethnic group, or race.

Contacts and Locations

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Locations

United States, Maryland
National Cancer Institute (NCI)
Bethesda, Maryland, United States, 20892

Sponsors and Collaborators

National Cancer Institute (NCI)

More Information

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Publications:

Carmelli D, Swan GE, Robinette D, Fabsitz RR. Heritability of substance use in the NAS-NRC Twin Registry. Acta Genet Med Gemellol (Roma). 1990;39(1):91-8.

Carmelli D, Swan GE, Robinette D, Fabsitz R. Genetic influence on smoking--a study of male twins. N Engl J Med. 1992 Sep 17;327(12):829-33.

Swan GE, Carmelli D, Rosenman RH, Fabsitz RR, Christian JC. Smoking and alcohol consumption in adult male twins: genetic heritability and shared environmental influences. J Subst Abuse. 1990;2(1):39-50.

ClinicalTrials.gov Identifier:	NCT00001500 History of Changes
Other Study ID Numbers:	960061; 96-C-0061
First Posted:	November 4, 1999
Last Update Posted:	March 4, 2008
Last Verified:	July 2004

Keywords provided by National Institutes of Health Clinical Center (CC):

Smoking; Alcohol; HIV; AIDS	DNA Markers; Personality; Healthy Volunteers; Normal Volunteer

Additional relevant MeSH terms:

HIV Infections; Immunologic Deficiency Syndromes; Acquired Immunodeficiency Syndrome; Alcoholism; Lentivirus Infections; Retroviridae Infections; RNA Virus Infections; Virus Diseases	Sexually Transmitted Diseases, Viral; Sexually Transmitted Diseases; Immune System Diseases; Slow Virus Diseases; Alcohol-Related Disorders; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders