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Genetic Factors and Interrelationships for Cancer Risk-Related Behaviors and Complex Traits
This study has been completed.
Sponsor:
National Cancer Institute (NCI)
Information provided by:
National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:
NCT00001500
First received: November 3, 1999
Last updated: March 3, 2008
Last verified: July 2004
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Purpose
We propose to conduct a multifactorial genetic study of cancer risk-related behaviors and other complex human characteristics. The main areas of interest are tobacco smoking, excess alcohol consumption, psychological traits, and HIV/AIDS susceptibility and progression. The subjects will be adult male and female probands who display one or more of the phenotypes of interest together with their brothers, sisters and parents. Information on tobacco and alcohol use, psychological and personality traits, sexual behavior, HIV status and progression, and other characteristics with possible genetic components will be obtained through structured interviews and questionnaires. DNA will be prepared from blood samples and typed for a series of candidate genes chosen for function and for random polymorphic markers. By correlating the genotypic and phenotypic information, we hope to identify individual loci that interactively contribute to many different aspects of human health and disease.
| Condition |
|---|
| Acquired Immunodeficiency Syndrome Alcoholism HIV Infection Neoplasm Smoking |
| Study Type: | Observational |
| Official Title: | Genetic Factors and Interrelationships for Cancer Risk-Related Behaviors and Complex Traits |
Resource links provided by NLM:
Further study details as provided by National Institutes of Health Clinical Center (CC):
| Estimated Enrollment: | 4500 |
| Study Start Date: | April 1996 |
| Estimated Study Completion Date: | July 2004 |
We propose to conduct a multifactorial genetic study of cancer risk-related behaviors and other complex human characteristics. The main areas of interest are tobacco smoking, excess alcohol consumption, psychological traits, and HIV/AIDS susceptibility and progression. The subjects will be adult male and female probands who display one or more of the phenotypes of interest together with their brothers, sisters and parents. Information on tobacco and alcohol use, psychological and personality traits, sexual behavior, HIV status and progression, and other characteristics with possible genetic components will be obtained through structured interviews and questionnaires. DNA will be prepared from blood samples and typed for a series of candidate genes chosen for function and for random polymorphic markers. By correlating the genotypic and phenotypic information, we hope to identify individual loci that interactively contribute to many different aspects of human health and disease.
Eligibility| Ages Eligible for Study: | Child, Adult, Senior |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | Yes |
Criteria
INCLUSION CRITERIA:
The basic requirement for entry in the study will be the presence of any individual smoker who is willing to complete the evaluation process and donate a blood sample.
Additional siblings will be encouraged but not required to participate.
Probands will be recruited through smoking cessation programs at the National Naval Medical Center.
Attendees at programs offered by the Health Promotions Department and the Military Family Health Center will be invited to participate in this study.
EXCLUSION CRITERIA:
All subjects will be adults (greater than 18 years).
There will be no exclusions based on sex, ethnic group, or race.
Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00001500
Please refer to this study by its ClinicalTrials.gov identifier: NCT00001500
Locations
| United States, Maryland | |
| National Cancer Institute (NCI) | |
| Bethesda, Maryland, United States, 20892 | |
Sponsors and Collaborators
National Cancer Institute (NCI)
More Information
Publications:
| ClinicalTrials.gov Identifier: | NCT00001500 History of Changes |
| Other Study ID Numbers: |
960061 96-C-0061 |
| Study First Received: | November 3, 1999 |
| Last Updated: | March 3, 2008 |
Keywords provided by National Institutes of Health Clinical Center (CC):
|
Smoking Alcohol HIV AIDS |
DNA Markers Personality Healthy Volunteers Normal Volunteer |
Additional relevant MeSH terms:
|
HIV Infections Immunologic Deficiency Syndromes Acquired Immunodeficiency Syndrome Alcoholism Lentivirus Infections Retroviridae Infections RNA Virus Infections Virus Diseases |
Sexually Transmitted Diseases, Viral Sexually Transmitted Diseases Immune System Diseases Slow Virus Diseases Alcohol-Related Disorders Substance-Related Disorders Chemically-Induced Disorders Mental Disorders |
ClinicalTrials.gov processed this record on June 27, 2017