Evaluation of Patients With Heart Disease Not Eligible for Research Protocols
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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT00001458 |
Recruitment Status :
Completed
First Posted : November 4, 1999
Last Update Posted : March 12, 2021
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An important mission of the National Institutes of Health (NIH) is to develop and carry out research studies designed to improve understanding of disease processes and treatments.
Clinical research continues to become more focused on specific diseases and the signs and symptoms of diseases in specific groups of people and patients.
This study is designed to permit inpatient evaluation and care of patients with heart disease who do not qualify to participate in research studies being conducted by the Cardiology Branch of the National Heart, Lung, and Blood Institute (NHLBI). These patients are valuable to the Cardiology Branch of the NHLBI because they help to improve training and experience of its researchers.
Condition or disease |
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Cardiovascular Disease |
Study Type : | Observational |
Actual Enrollment : | 7829 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Diagnosis and Treatment of Patients With Heart and Vascular Disease (Training Protocol) |
Actual Study Start Date : | January 1, 1995 |
Actual Primary Completion Date : | July 28, 2020 |
Actual Study Completion Date : | July 28, 2020 |
Group/Cohort |
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Cardiovascular
subjects with cardiovascular symptoms or known disease.
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- training of staff [ Time Frame: 20 years ]staff becomes familiar or proficient in cardiovascular diagnostic studies.

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | up to 99 Years (Child, Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
- INCLUSION CRITERIA:
Patients with signs or symptoms or risk of cardiovascular disease may participate in this training protocol. The following is a representative list of the types of patient presentations and potential diagnoses eligible for this protocol:
Coronary artery disease with effort or rest angina or inducible myocardial ischemia as determined by noninvasive testing.
Valvular heart disease.
Cardiomyopathies, including restrictive, congestive, and hypertrophic phenotypes.
Peripheral-artery disease of upper or lower extremities, with intermittent pain with activity (e.g. claudication) or limb-threatening ischemia.
Renovascular disease with uncontrolled hypertension, intermittent pulmonary edema, or evidence of ischemic nephropathy.
Congenital heart disease, with communications between chambers or major vessels
Heart surgery patients treated at the Clinical Center prior to closure of the Heart Surgery Branch in 1990
EXCLUSION CRITERIA:
Pregnancy, for those patients who require testing or treatment requiring dobutamine, gadolinium or contrast media or radiation exposure.
Inability of patient, parent or legal guardian to provide informed consent.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001458
United States, Maryland | |
National Institutes of Health Clinical Center, 9000 Rockville Pike | |
Bethesda, Maryland, United States, 20892 |
Principal Investigator: | Alessandra Brofferio, M.D. | National Heart, Lung, and Blood Institute (NHLBI) |
Responsible Party: | National Heart, Lung, and Blood Institute (NHLBI) |
ClinicalTrials.gov Identifier: | NCT00001458 |
Other Study ID Numbers: |
950047 95-H-0047 |
First Posted: | November 4, 1999 Key Record Dates |
Last Update Posted: | March 12, 2021 |
Last Verified: | July 2020 |
Studies a U.S. FDA-regulated Drug Product: | No |
Studies a U.S. FDA-regulated Device Product: | No |
Cardiovascular Treatment Cardiovascular Disease Cardiovascular Testing Heart Disease Muscle Leg Pain Leg Pain |
Circulation Peripheral Arterial Disease Intermittent Claudication Renal Vascular Disease Uncontrolled Hypertension |
Cardiovascular Diseases |