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Mapping the Areas of the Brain Associated With Language in Children With Epilepsy

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00001366
Recruitment Status : Completed
First Posted : November 4, 1999
Last Update Posted : March 4, 2008
Information provided by:
National Institutes of Health Clinical Center (CC)

Brief Summary:

Researchers are interested in studying if magnetic resonance imaging (MRI) is practical for locating the areas of the brain associated with language in children with epilepsy.

When a region of the brain is active, it uses more fuel in the form of oxygen and sugar (glucose). As the brain uses more fuel it produces more waste products, carbon dioxide and water. Blood carries fuel to the brain and waste products away from the brain. As brain activity increases blood flow to and from the area of activity increases also.

Patients participating in the study will be asked to perform tasks designed to test language skills while undergoing an MRI to detect areas of the brain using oxygen and receiving blood flow.

Condition or disease
Epilepsy Seizures

Detailed Description:
We propose to study the feasibility of utilizing MRI to perform functional mapping of language cortex in children with epilepsy. We will use 1.5 Tesla MRI to study cerebral blood flow and tissue oxygenation during cognitive activation tasks derived from previous adult studies.

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Study Type : Observational
Enrollment : 230 participants
Official Title: MRI-Based Functional Language Mapping in Children With Epilepsy
Study Start Date : August 1993
Study Completion Date : September 2002

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Epilepsy

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Children aged 5-17 years.

Partial epilepsy (localized).

Ability to cooperate with task paradigms (IQ greater than 65).

No cardiac pacemakers, cochlear implants, shrapnel, vascular clips, braces, or claustrophobia.

No one with inability to cooperate with task paradigms.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00001366

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United States, Maryland
National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
National Institute of Neurological Disorders and Stroke (NINDS)

Layout table for additonal information Identifier: NCT00001366     History of Changes
Other Study ID Numbers: 930191
First Posted: November 4, 1999    Key Record Dates
Last Update Posted: March 4, 2008
Last Verified: September 2002
Keywords provided by National Institutes of Health Clinical Center (CC):
Cerebral Localization
Partial Epilepsy
Additional relevant MeSH terms:
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Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms