Studies of Frontal Lobe Brain Functioning in Schizophrenia
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|ClinicalTrials.gov Identifier: NCT00001258|
Recruitment Status : Completed
First Posted : November 4, 1999
Last Update Posted : August 24, 2020
The purpose of this study is to use brain imaging technology to investigate the role of the frontal lobe of the brain in the thinking of individuals with schizophrenia and other neuropsychiatric disorders and healthy volunteers.
Participants in this study will undergo a positron emission tomography (PET) scan of the brain while performing neuropsychological tests. Some of the tests involve cognitive operations that depend upon the frontal cortex. Interactions between frontal lobe activation, cognitive behavior, and neuropharmacology will be assessed by measuring regional cerebral blood flow (rCBF) during treatment with drugs that may affect frontal lobe physiology.
|Condition or disease|
|Healthy Subjects Schizophrenia Parkinson Disease|
|Study Type :||Observational|
|Actual Enrollment :||1039 participants|
|Official Title:||Studies of Frontal Lobe Function During Cognitive Stimulation as Measured With Oxygen-15 Water Positron Emission Tomography in Normal Subjects and Patients With Neuropsychiatric Disorders|
|Actual Study Start Date :||November 26, 1993|
Patients with schizophrenia spectrum disorder
- Differences between rCBF during the frontal lobe tasks and rCBF during the sensorimotor control [ Time Frame: ongoing ]ongoing
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001258
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike|
|Bethesda, Maryland, United States, 20892|
|Principal Investigator:||Karen F Berman, M.D.||National Institute of Mental Health (NIMH)|