Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers

• Description of study populations:

Participants include typically developing subjects, subjects with a variety of neuropsychiatric conditions, and those with anomalous sex chromosome numbers or endocrine conditions.

The accrual ceiling is 6,000.

INCLUSION CRITERIA FOR HEALTHY CONTROLS:

Subjects consenting to participation in the study

Over 3 years of age with no upper limit for age at time of enrollment.

INCLUSION CRITERIA FOR MRI SCANNER CALIBRATION PROJECT:

Participants will meet protocol criteria for adult healthy volunteers

ADDITIONAL INCLUSION AND EXCLUSION CRITERIA FOR RETROSPECTIVE NEUROPSYCHOLOGICAL DATA COLLECTION:

INCLUSION CRITERIA:

At least 18 years of age

Previous qualifications as a healthy participant

At least 3 high quality structural MRI scans between the ages of 7 and 30 years.

Sufficient physical measures to ascertain growth during adolescence

INCLUSION CRITERIA FOR PATIENT POPULATIONS:

Male and female subjects over 3 years of age with no upper limit for age (with the exception of the Down syndrome group see below). Currently meet criteria for at least one of the following:

DSM-IV (or other approved) criteria for one of the following clinical diagnoses: Multi-Dimensionally Impaired, Obsessive Compulsive Disorder, Childhood Onset Schizophrenia, Turner Syndrome, Autism Spectrum Disorder, Asperger Syndrome, High Functioning Autism, Pervasive Development Disorder

Sex chromosome aneuploidy as determined by karyotype (including XXX, XXXX, XXXXX, XXY, XXYY, XXXY, XXXXY, XYY).

ICD-10 criteria for Congenital Adrenal Hyperplasia, Cushings Syndrome, Kallmann Syndrome, normosmic hypogonadotropic hypogonadism, Androgen Insensitivity Syndrome

ADHD

Down s Syndrome

Newly enrolled adults and minors once they become adults over age 18 who cannot give consent due to limited capacity may have a surrogate, i.e., a legally responsible representative (LAR), sign the consent. LARs include DPA holders, court-appointed legal guardians, or parents or siblings over 18 years of age. We will consult with the Human Subjects Protection Unit as necessary.

ADDITIONAL INCLUSION CRITERIA FOR ADHD PARTICIPANTS:

Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) defined ADHD. The DSM-IV diagnosis of ADHD will be based on the Parent Diagnostic Interview for Children and Adolescents.

Conners Teacher Hyperactivity rating greater than 2 SD above age- and sex-specific means.

ADDITIONAL INCLUSION CRITERIA FOR DOWN SYNDROME PARTICIPANTS:

Confirmed chromosomal diagnosis of Down syndrome.

Age at entry into the study is 30 years or under.

ADDITIONAL INCLUSION CRITERIA FOR PARTICIPANTS WITH AUTISM SPECTRUM DISORDERS:

Meeting DSM-IV criteria for one of the pervasive developmental disorders (i.e., autistic disorder, Asperger disorder, or pervasive developmental disorder-not otherwise specified).

Having a minimum IQ of 70.

EXCLUSION CRITERIA:

NIMH staff and their immediate family are excluded from participation.

EXCLUSION CRITERIA FOR HEALTHY CONTROLS:

Presence of any psychiatric disorder in the subject, sibling, or other first-degree relative.

Current or past use of psychiatric medication.

Special service needs in school.

Presence or history of medical conditions known to affect cerebral anatomy.

Dental braces.

Metal in the body or other contraindications for MRI scanning.

For females who have reached menarche: Pregnancy or inability or unwillingness to undergo pregnancy testing.

ADDITIONAL EXCLUSION CRITERIA FOR RETROSPECTIVE NEUROPSYCHOLOGICAL DATA COLLECTION:

Presence of any psychiatric disorder in the subject.

Current or past use of psychiatric medication.

Presence or history of medical conditions known to affect cerebral anatomy.

EXCLUSION CRITERIA FOR ALL PATIENT POPULATIONS:

Dental braces.

Metal in the body or other contraindications for MRI scanning.

For females who have reached menarche: Pregnancy or inability or unwillingness to undergo pregnancy testing.

Evidence of another medical condition or traumatic event known to affect cerebral anatomy.

A known genetic disorder (other than the condition under investigation) that would be expected to significantly impact findings from cognitive testing and/or neuroimaging.

ADDITIONAL EXCLUSION CRITERIA FOR ADHD PARTICIPANTS:

A full-scale IQ of less than 80.

Birth before 34 weeks of gestation.

Other axis I psychiatric disorder requiring treatment with medication at study entry (with the exception of oppositional-defiant disorder).