Studies of States With Resistance to Vitamin D and Parathyroid Hormone
![]() |
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT00001242 |
Recruitment Status :
Recruiting
First Posted : November 4, 1999
Last Update Posted : April 21, 2021
|
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Condition or disease |
---|
Hypocalcemia Pseudohypoparathyroidism Osteomalacia Rickets Pseudopseudohpoparathyroidism |
Study Type : | Observational |
Estimated Enrollment : | 3000 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Studies of States With Resistance to Vitamin D and Parathyroid Hormone |
Actual Study Start Date : | August 12, 1997 |

Group/Cohort |
---|
Study Cohort
Patients of any age or sex with vitamin D resistance, rickets, osteomalacia, pseudohypoparathyroidism, pseudo- pseudohypoparathyroidism, or suspicion of these or related disorders
|
- This study will provide information about problems relating to calcium in the blood, urine, and bones [ Time Frame: take one to two weeks ]This is a natural history protocol, directed at diagnosing and managing the general clinical features in these patients. In addition the full clinical expression of certain rare disorders (target resistance to 1,25(OH)2D, pseudohypoparathyroidism, and pseudo- pseudohypoparathyroidism) will be characterized further. Some of these patients or their relatives will be entered into additional protocols, where appropriate for example, protocols to characterize the molecular causes of these disorders.

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 2 Months to 100 Years (Child, Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
- INCLUSION CRITERIA:
Patients, from 2 months to 100 years of age, of either sex M or F, with vitamin D resistance, rickets, osteomalacia, pseudohypoparathyroidism, pseudo-pseudohypoparathyroidism, or suspicion of these or related disorders based upon the appropriateness of their problem to ongoing investigations.
Current investigations are focused principally upon the inclusion of subjects with, or suspected of having, hypocalcemia likely due to a resistance to parathyroid hormone, including subjects who have a diagnosis, or likely diagnosis, of pseudohypoparathyroidism or pseudopseudohypoparathyroidism.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001242
Contact: Craig S Cochran, R.N. | (301) 402-1880 | craigc@bdg10.niddk.nih.gov | |
Contact: Lee S Weinstein, M.D. | (301) 402-2923 | leew@mail.nih.gov |
United States, Maryland | |
National Institutes of Health Clinical Center, 9000 Rockville Pike | Recruiting |
Bethesda, Maryland, United States, 20892 | |
Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 prpl@cc.nih.gov |
Principal Investigator: | Lee S Weinstein, M.D. | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
Publications:
Responsible Party: | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
ClinicalTrials.gov Identifier: | NCT00001242 |
Other Study ID Numbers: |
890173 89-DK-0173 |
First Posted: | November 4, 1999 Key Record Dates |
Last Update Posted: | April 21, 2021 |
Last Verified: | April 16, 2021 |
Rickets Hypocalcemia Albright Hereditary Osteodystrophy Pseudohypoaldosteronism |
Rickets Osteomalacia Pseudohypoparathyroidism Pseudopseudohypoparathyroidism Hypocalcemia Calcium Metabolism Disorders Metabolic Diseases Water-Electrolyte Imbalance Bone Diseases, Metabolic Bone Diseases |
Musculoskeletal Diseases Vitamin D Deficiency Avitaminosis Deficiency Diseases Malnutrition Nutrition Disorders Metal Metabolism, Inborn Errors Metabolism, Inborn Errors Genetic Diseases, Inborn |