Comparing Magnetic Resonance Imaging/Spectroscopy Techniques

This study is currently recruiting participants. (see Contacts and Locations)
Verified May 2015 by National Institutes of Health Clinical Center (CC)
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) Identifier:
First received: November 3, 1999
Last updated: April 27, 2016
Last verified: May 2015

Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) are diagnostic tests that allow researchers to look at different chemical properties of tissue. Magnetic resonance imaging and spectroscopy studies can be used to gather or evaluate information about various aspects of patient s bodies or to monitor changes in the biochemistry and physiology of patient s bodies.

Unlike other diagnostic techniques (CT scan and PET scan) MRI and MRS do not use ionizing radiation. Some studies have shown that MRI is more effective at distinguishing normal parts of the anatomy from abnormal anatomy, especially in the brain. MRI has become the diagnostic test of choice for evaluating patient with multiple sclerosis.

The purpose of this study is to evaluate normal volunteers and patients with a variety of diseases with magnetic resonance imaging. Researchers will attempt different magnetic resonance imaging methods and techniques as well as different levels of magnetic strength.

MRI Scans

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Magnetic Resonance Imaging at 1.5 and 3.0 Tesla

Resource links provided by NLM:

Further study details as provided by National Institutes of Health Clinical Center (CC):

Primary Outcome Measures:
  • Success of new sequences [ Time Frame: 10 scan comparison ] [ Designated as safety issue: No ]

Estimated Enrollment: 99999999
Study Start Date: June 1987
Detailed Description:
MRI is a constantly evolving imaging modality and MR. Pulse sequences are often modified to improve their performance. However, many of these changes have not yet been approved by the FDA and therefore, are not considered standard of care. Some of these sequences require the use of new types of imaging coils, which are also investigational. The major purpose of this protocol is to inform patients undergoing MR scans in the Clinical Center that they may undergo scans that are not FDA approved and to get the patient's consent for this. This is not a formal research study since specific disease entities and specific pulse sequences are not studied in a systematic way. Rather, the purpose is to give NIH patients access to gradual improvements in MR technology that would otherwise not be available to them. A secondary purpose is to inform patients about the risks of MRI and gadolinium chelates which are commonly employed in MRI.

Ages Eligible for Study:   up to 99 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

All patients undergoing MRI in the Clinical Center.

Patients must be able to provide informed consents.


No contraindications to MRI.

Inability to understand consent form or consent process and the absence of a suitable guardian.

Refusal to Participate.

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00001219

Contact: John A Butman, M.D. (301) 402-5827

United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting
Bethesda, Maryland, United States, 20892
Contact: For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL)    800-411-1222 ext TTY8664111010   
Sponsors and Collaborators
National Institutes of Health Clinical Center (CC)
Principal Investigator: John A Butman, M.D. National Institutes of Health Clinical Center (CC)
  More Information

Additional Information:
Responsible Party: National Institutes of Health Clinical Center (CC) Identifier: NCT00001219     History of Changes
Other Study ID Numbers: 870091  87-CC-0091 
Study First Received: November 3, 1999
Last Updated: April 27, 2016
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
Magnetic Resonance Imaging
Pulse Sequences processed this record on April 27, 2016