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Brain Study of Patients With Frontal Lobe Dementia and Parkinsonian Disorders

This study has been terminated.
Information provided by:
National Institutes of Health Clinical Center (CC) Identifier:
First received: November 3, 1999
Last updated: April 19, 2017
Last verified: December 17, 2012
The Cognitive Neuroscience Section of the National Institute of Neurological Disorders and Stroke proposes to continue its cross-sectional and longitudinal studies of cerebral metabolism in frontal lobe dementias and atypical basal ganglia disorders. These studies include repeated assessments of neuropsychological and brain anatomical and metabolic function in subjects with these important and possibly related brain disorders.

Alzheimer's Disease
Down's Syndrome

Study Type: Observational
Official Title: Regional Cerebral Utilization of Glucose in Patients With a Diagnosis of Frontal Lobe Dementia, Atypical Parkinsonian Disorder, and Other Basal Ganglia Disorders

Resource links provided by NLM:

Further study details as provided by National Institutes of Health Clinical Center (CC):

Enrollment: 597
Study Start Date: January 19, 1981
Estimated Study Completion Date: December 17, 2012
Detailed Description:


To continue the cross-sectional and longitudinal studies performed by the Cognitive Neuroscience Section of NINDS on the neuroanatomy, cerebral metabolism, neuropsychology, and genetics of frontotemporal dementia, corticobasal syndrome, and related brain disorders.

Study population

Frontal lobe dementias and atypical basal ganglia disorders including frontotemporal dementia, corticobasal syndrome, and related brain disorders.


A cross-sectional assessment of neuropsychological, brain anatomical and metabolic function, and genetic measures in subjects with these disorders.

Outcome measures

MRI, FDG-PET, neuropsychological and clinical tests, genetics, and neuropathology.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
  • Subjects will be recruited from the NIH referral center, neurological and psychiatric clinics, from self or family referral in response to advertisements or from private physicians. Healthy volunteers will include subjects who are considered at-risk for the development of FTD or CBS and subjects who serve as normal controls matched for key characteristics with the patients.


  • Diagnosis of possible / probable FTD or CBS
  • Caregiver willing and able to accept the responsibilities involved in the study


  • Pregnant women. Women of childbearing potential will be screened by history for the possibility of pregnancy and undergo a urine pregnancy test. These women will be excluded from the imaging portions of the protocol.
  • Behavioral symptoms that would preclude the gathering of data for the study
  • Other medical or social condition that would preclude participation in the opinion of the investigators
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00001178

United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
National Institute of Neurological Disorders and Stroke (NINDS)
Principal Investigator: Eric M Wassermann, M.D. National Institute of Neurological Disorders and Stroke (NINDS)
  More Information

Publications: Identifier: NCT00001178     History of Changes
Other Study ID Numbers: 810010
Study First Received: November 3, 1999
Last Updated: April 19, 2017

Keywords provided by National Institutes of Health Clinical Center (CC):
Alzheimer's Disease
Cerebral Metabolism
Cerebrospinal Fluid
Dementia of the Alzheimer Type
18-F-Fluoro-2-Deoxy-D-Glucose (FDG)
Magnetic Resonance Imaging
Positron Emission Tomography
X-Ray Computed Tomography (CT)
Senile Dementia
Down Syndrome
Trisomy 21

Additional relevant MeSH terms:
Parkinsonian Disorders
Alzheimer Disease
Down Syndrome
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders
Intellectual Disability
Neurobehavioral Manifestations
Neurologic Manifestations
Abnormalities, Multiple
Congenital Abnormalities
Chromosome Disorders
Genetic Diseases, Inborn
Basal Ganglia Diseases
Movement Disorders processed this record on April 28, 2017