Evaluation of Patients With Thyroid Disorders

Study Description

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Brief Summary:

Participants in this study will be patients diagnosed with or suspected to have a thyroid function disorder. These conditions may include: hypothyroidism, hyperthyroidism, thyroid hormone resistance, Graves' Dermopathy, and thyroid-stimulating hormone (TSH) secreting pituitary adenomas.

The main purpose of this study is to further understand the natural history, clinical presentation, and genetics of thyroid function disorders. Many of the tests performed are in the context of standard medical care that is offered to all patients with thyroid function disorders. In addition, blood and tissue samples may be taken for research and genetic studies.

Condition or disease
Hyperthyroidism; Hypothyroidism

Detailed Description:

Patients with thyroid function abnormalities (hyperthyroidism, hypothyroidism) are studied and

treated in this protocol. A limited number of patients with a personal history of signs, symptoms or laboratory studies consistent with thyroid dysfunction or a strong family history of thyroid abnormalities are also enrolled. Patients undergo routine history and physical examination, standard endocrine blood and urine tests, a standard TRH test, thyroid nuclear medicine scan, thyroidal radioiodine (RAI) or technetium (99mTc) uptake measurements, as well as X-ray, computed tomography (CT) or magnetic resonance imaging (MRI) studies or other standard diagnostic procedures, as clinically indicated. Patients will be screened for entry into other research studies.

Study Design

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Study Type :	Observational
Estimated Enrollment :	99999999 participants
Observational Model:	Case-Only
Time Perspective:	Retrospective
Official Title:	Evaluation of Patients With Thyroid Function Disorders
Study Start Date :	January 14, 1977

Groups and Cohorts

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Outcome Measures

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Primary Outcome Measures :

1. Evaluation of Thyroid disorders.

Eligibility Criteria

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Ages Eligible for Study:	Child, Adult, Senior
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	No

Criteria

• INCLUSION CRITERIA:

Patients of any age with known or suspected thyroid abnormalities may be included in this study. These disorders can be broadly defined as hyper- or hypothyroid states and laboratory abnormalities.

Contacts and Locations

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Contacts

Contact: Craig S Cochran, R.N.	(301) 402-1880	craigc@bdg10.niddk.nih.gov
Contact: Joanna Klubo-Gwiezdzinska, M.D.	(301) 496-5052	joanna.klubo-gwiezdzinska@nih.gov

Locations

United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike	Recruiting
Bethesda, Maryland, United States, 20892
Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 prpl@cc.nih.gov

Sponsors and Collaborators

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Investigators

Principal Investigator:	Joanna Klubo-Gwiezdzinska, M.D.	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

More Information

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Additional Information:

NIH Clinical Center Detailed Web Page 

Publications:

Holland FW 2nd, Brown PS Jr, Weintraub BD, Clark RE. Cardiopulmonary bypass and thyroid function: a "euthyroid sick syndrome". Ann Thorac Surg. 1991 Jul;52(1):46-50.

Chanson P, Weintraub BD, Harris AG. Octreotide therapy for thyroid-stimulating hormone-secreting pituitary adenomas. A follow-up of 52 patients. Ann Intern Med. 1993 Aug 1;119(3):236-40.

Brucker-Davis F, Skarulis MC, Grace MB, Benichou J, Hauser P, Wiggs E, Weintraub BD. Genetic and clinical features of 42 kindreds with resistance to thyroid hormone. The National Institutes of Health Prospective Study. Ann Intern Med. 1995 Oct 15;123(8):572-83.

Responsible Party:	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ClinicalTrials.gov Identifier:	NCT00001159 History of Changes
Other Study ID Numbers:	770002; 77-DK-0002
First Posted:	November 4, 1999
Last Update Posted:	March 29, 2018
Last Verified:	March 16, 2018

Keywords provided by National Institutes of Health Clinical Center (CC) ( National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) ):

Hyperthyroidism; Hypothyroidism; Thyroid-Stimulating Hormone Secreting Pituitary Adenomas

Additional relevant MeSH terms:

Hypothyroidism; Hyperthyroidism; Thyroid Diseases; Endocrine System Diseases