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Thalassemia (Cooley's Anemia) Clinical Research Network (TCRN)

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ClinicalTrials.gov Identifier: NCT00000623
Recruitment Status : Completed
First Posted : October 28, 1999
Last Update Posted : March 4, 2014
Sponsor:
Collaborators:
National Heart, Lung, and Blood Institute (NHLBI)
Thalassemia Clinical Research Network
Information provided by:
New England Research Institutes

Brief Summary:
The purpose of the TCRN is to accelerate research in the management of thalassemia, standardize existing treatments, and evaluate new ones in a network of clinical centers in North America. The emphasis will be on clinical trials that help identify optimal therapy. Therapeutic trials may involve investigational drugs, drugs already approved but not currently used, and drugs currently used.

Condition or disease Intervention/treatment
Anemia, Cooley's Beta-Thalassemia Hematologic Diseases Thalassemia Osteoporosis Iron Overload Hypertension, Pulmonary Drug: Deferoxamine Drug: Deferiprone Drug: Arginine Drug: Sildenafil Drug: Decitabine

  Show Detailed Description

Study Type : Observational
Estimated Enrollment : 1000 participants
Time Perspective: Prospective
Official Title: Thalassemia Clinical Research Network (TCRN)
Study Start Date : July 2000
Actual Study Completion Date : July 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Thalassemia
U.S. FDA Resources




Primary Outcome Measures :
  1. Vary by protocol


Information from the National Library of Medicine

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Ages Eligible for Study:   1 Year to 75 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria
Please refer to specific studies for eligibility criteria.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00000623


Locations
United States, California
Children's Hospital Oakland
Oakland, California, United States, 94609
United States, Massachusetts
Children's Hospital
Boston, Massachusetts, United States, 02115
United States, New York
Weill Medical College of Cornell University
New York, New York, United States, 10021
United States, Pennsylvania
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Canada, Ontario
Toronto General Hospital
Toronto, Ontario, Canada, M5G 2C4
Sponsors and Collaborators
New England Research Institutes
National Heart, Lung, and Blood Institute (NHLBI)
Thalassemia Clinical Research Network
Investigators
Principal Investigator: Alan R. Cohen, MD Children's Hospital of Philadelphia
Principal Investigator: Patricia J. Giardina, MD Weill Medical College of Cornell University
Principal Investigator: Ellis J. Neufeld, MD, PhD Children's Hospital Medical Center, Cincinnati
Principal Investigator: Nancy F. Olivieri, MD Toronto General Hospital
Principal Investigator: Elliott P. Vichinsky, MD Children's Hospital & Research Center Oakland
Principal Investigator: Sonja McKinlay, PhD New England Research Institutes, Inc.

Publications:
ClinicalTrials.gov Identifier: NCT00000623     History of Changes
Other Study ID Numbers: 317
U01HL065232 ( U.S. NIH Grant/Contract )
U01HL065233 ( U.S. NIH Grant/Contract )
U01HL065238 ( U.S. NIH Grant/Contract )
U01HL065239 ( U.S. NIH Grant/Contract )
U01HL065244 ( U.S. NIH Grant/Contract )
U01HL065260 ( U.S. NIH Grant/Contract )
First Posted: October 28, 1999    Key Record Dates
Last Update Posted: March 4, 2014
Last Verified: July 2006

Keywords provided by New England Research Institutes:
chelator
iron
transfusion
anemia
thalassemia

Additional relevant MeSH terms:
Thalassemia
beta-Thalassemia
Anemia
Osteoporosis
Iron Overload
Hematologic Diseases
Hypertension, Pulmonary
Bone Diseases, Metabolic
Bone Diseases
Musculoskeletal Diseases
Metabolic Diseases
Anemia, Hemolytic, Congenital
Anemia, Hemolytic
Hemoglobinopathies
Genetic Diseases, Inborn
Iron Metabolism Disorders
Lung Diseases
Respiratory Tract Diseases
Sildenafil Citrate
Decitabine
Deferiprone
Deferoxamine
Vasodilator Agents
Phosphodiesterase 5 Inhibitors
Phosphodiesterase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Urological Agents
Antimetabolites, Antineoplastic
Antimetabolites