Women's Health Initiative (WHI)

This study has been completed.
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier:
First received: October 27, 1999
Last updated: November 12, 2014
Last verified: January 2006

To address cardiovascular disease, cancer, and osteoporosis, the most common causes of death, disability, and impaired quality of life in postmenopausal women. The three major components of the WHI are: a randomized controlled clinical trial of hormone replacement therapy (HRT), dietary modification (DM), and calcium/vitamin D supplementation (CaD); an observational study (OS); and a community prevention study (CPS). On October 1, 1997, administration of the WHI was transferred to the NHLBI where it is conducted as a consortium effort led by the NHLBI in cooperation with the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Cancer Institute (NCI), and the National Institute on Aging (NIA).

Condition Intervention Phase
Bone Diseases
Breast Neoplasms
Cardiovascular Diseases
Colonic Neoplasms
Coronary Disease
Heart Diseases
Myocardial Ischemia
Drug: hormone replacement therapy
Drug: estrogens
Drug: progestins
Drug: estrogen replacement therapy
Behavioral: diet, fat-restricted
Drug: calcium
Drug: vitamin D
Behavioral: dietary supplements
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Primary Purpose: Prevention

Resource links provided by NLM:

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Primary Completion Date: March 2005 (Final data collection date for primary outcome measure)
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Ages Eligible for Study:   50 Years to 79 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No

Postmenopausal women ages 50 to 79.

  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00000611

Sponsors and Collaborators
Investigator: Ross Prentice Fred Hutchinson Cancer Research Center
  More Information

Additional Information:

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

ClinicalTrials.gov Identifier: NCT00000611     History of Changes
Other Study ID Numbers: 114
Study First Received: October 27, 1999
Last Updated: November 12, 2014
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Myocardial Ischemia
Cardiovascular Diseases
Heart Diseases
Vascular Diseases
Hormones, Hormone Substitutes, and Hormone Antagonists
Pharmacologic Actions
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on March 30, 2015