Mode Selection Trial in Sinus Node Dysfunction (MOST)

This study has been completed.
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI) Identifier:
First received: October 27, 1999
Last updated: June 23, 2005
Last verified: May 2005

To determine if dual chamber rate-modulated pacing (DDDR) in patients with sick sinus syndrome is superior to single chamber pacing (VVIR) with respect to subsequent frequency of adverse clinical events such as stroke, quality of life and function, and cost effectiveness.

Condition Intervention Phase
Cardiovascular Diseases
Heart Diseases
Sick Sinus Syndrome
Vascular Diseases
Cerebrovascular Accident
Device: pacemaker, artificial
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date: June 1995
Estimated Study Completion Date: May 2002
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Ages Eligible for Study:   18 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Men and women with sick sinus syndrome.

  Contacts and Locations
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Please refer to this study by its identifier: NCT00000561

Sponsors and Collaborators
Investigator: Gervasio Lamas Mount Sinai School of Medicine
Investigator: Kerry Lee Duke University
  More Information

Publications: Identifier: NCT00000561     History of Changes
Other Study ID Numbers: 105
Study First Received: October 27, 1999
Last Updated: June 23, 2005
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Sick Sinus Syndrome
Cerebral Infarction
Arrhythmia, Sinus
Arrhythmias, Cardiac
Brain Diseases
Brain Infarction
Brain Ischemia
Cardiovascular Diseases
Central Nervous System Diseases
Cerebrovascular Disorders
Heart Block
Heart Diseases
Nervous System Diseases
Pathologic Processes
Vascular Diseases processed this record on March 26, 2015