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Mode Selection Trial in Sinus Node Dysfunction (MOST)

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ClinicalTrials.gov Identifier: NCT00000561
Recruitment Status : Completed
First Posted : October 28, 1999
Last Update Posted : February 23, 2016
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Study Description
Brief Summary:
To determine if dual chamber rate-modulated pacing (DDDR) in patients with sick sinus syndrome is superior to single chamber pacing (VVIR) with respect to subsequent frequency of adverse clinical events such as stroke, quality of life and function, and cost effectiveness.

Condition or disease Intervention/treatment Phase
Arrhythmia Cardiovascular Diseases Heart Diseases Sick Sinus Syndrome Vascular Diseases Cerebrovascular Accident Device: pacemaker, artificial Phase 3

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Study Design

Study Type : Interventional  (Clinical Trial)
Allocation: Randomized
Primary Purpose: Treatment
Study Start Date : June 1995
Estimated Study Completion Date : May 2002

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U.S. FDA Resources

Arms and Interventions

Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Men and women with sick sinus syndrome.
Contacts and Locations

Information from the National Library of Medicine

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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00000561

Sponsors and Collaborators
Mt. Sinai Medical Center, Miami
National Heart, Lung, and Blood Institute (NHLBI)
OverallOfficial: Gervasio Lamas Icahn School of Medicine at Mount Sinai
OverallOfficial: Kerry Lee Duke University
More Information


ClinicalTrials.gov Identifier: NCT00000561     History of Changes
Other Study ID Numbers: 105
U01HL049804 ( U.S. NIH Grant/Contract )
First Posted: October 28, 1999    Key Record Dates
Last Update Posted: February 23, 2016
Last Verified: May 2005

Additional relevant MeSH terms:
Sick Sinus Syndrome
Cardiovascular Diseases
Heart Diseases
Vascular Diseases
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Arrhythmia, Sinus
Arrhythmias, Cardiac
Heart Block
Pathologic Processes