Mode Selection Trial in Sinus Node Dysfunction (MOST)

This study has been completed.
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:
Mt. Sinai Medical Center, Miami Identifier:
First received: October 27, 1999
Last updated: February 22, 2016
Last verified: May 2005
To determine if dual chamber rate-modulated pacing (DDDR) in patients with sick sinus syndrome is superior to single chamber pacing (VVIR) with respect to subsequent frequency of adverse clinical events such as stroke, quality of life and function, and cost effectiveness.

Condition Intervention Phase
Cardiovascular Diseases
Heart Diseases
Sick Sinus Syndrome
Vascular Diseases
Cerebrovascular Accident
Device: pacemaker, artificial
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by Mt. Sinai Medical Center, Miami:

Study Start Date: June 1995
Estimated Study Completion Date: May 2002
  Show Detailed Description


Ages Eligible for Study:   18 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Men and women with sick sinus syndrome.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00000561

Sponsors and Collaborators
Mt. Sinai Medical Center, Miami
National Heart, Lung, and Blood Institute (NHLBI)
OverallOfficial: Gervasio Lamas Icahn School of Medicine at Mount Sinai
OverallOfficial: Kerry Lee Duke University
  More Information

Publications: Identifier: NCT00000561     History of Changes
Other Study ID Numbers: 105  U01HL049804 
Study First Received: October 27, 1999
Last Updated: February 22, 2016
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Sick Sinus Syndrome
Cardiovascular Diseases
Vascular Diseases
Arrhythmia, Sinus
Arrhythmias, Cardiac
Brain Diseases
Central Nervous System Diseases
Cerebrovascular Disorders
Heart Block
Heart Diseases
Nervous System Diseases
Pathologic Processes processed this record on May 24, 2016