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Hypertension Prevention Trial (HPT) Feasibility Study

This study has been completed.
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI) Identifier:
First received: October 27, 1999
Last updated: November 25, 2013
Last verified: April 2012
To test the feasibility and the efficacy of nutritional interventions in the primary prevention of hypertension in individuals predisposed to the development of hypertension; specifically, to test the hypothesis that reduction of weight and/or decreased sodium intake in obese individuals, or decreased sodium intake with or without increased potassium intake (in men and women, regardless of weight) would prevent the elevation of blood pressure and the incidence of hypertension.

Condition Intervention Phase
Cardiovascular Diseases
Heart Diseases
Vascular Diseases
Behavioral: diet, sodium-restricted
Behavioral: diet, reducing
Drug: potassium
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Primary Purpose: Prevention

Resource links provided by NLM:

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date: September 1981
Study Completion Date: August 1986
  Show Detailed Description


Ages Eligible for Study:   25 Years to 49 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Men and women, ages 25 to 49. Diastolic blood pressure between 78 and 89 mm Hg. Free of major disease. Not on a special diet or antihypertensive medication at entry. Some mild to moderately obese subjects.
  Contacts and Locations
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Please refer to this study by its identifier: NCT00000501

Sponsors and Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
OverallOfficial: Nemat Borhani University of California, Davis
OverallOfficial: Robert Jeffery University of Minnesota - Clinical and Translational Science Institute
OverallOfficial: Herbert Langford University of Mississippi Medical Center
OverallOfficial: Albert Oberman University of Alabama at Birmingham
OverallOfficial: Ronald Prineas University of Minnesota - Clinical and Translational Science Institute
  More Information

Hypertension Prevention Trial Research Group: Hypertension Prevention Trial--First Year Dietary Changes. In Strasser T, Ganten D, (Eds.). Mild Hypertension: From Drug Trials to Practice, New York, Raven Press, 1987.
Tonascia J, Donithan M, Tonascia S, et al for the Hypertension Prevention Trial Research Group: Hypertension Prevention Trial: Estimation of 24-hour Sodium and Potassium Excretion from Overnight Urine Collections. Baltimore, Maryland, Department of Biostatistics, Johns Hopkins University, Technical Report 703, 1989. Identifier: NCT00000501     History of Changes
Other Study ID Numbers: 20
R01HL026585-07 ( US NIH Grant/Contract Award Number )
Study First Received: October 27, 1999
Last Updated: November 25, 2013

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Vascular Diseases processed this record on May 25, 2017