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Lipid Research Clinics Coronary Primary Prevention Trial (CPPT)

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ClinicalTrials.gov Identifier: NCT00000488
Recruitment Status : Completed
First Posted : October 28, 1999
Last Update Posted : April 14, 2016
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)

Brief Summary:

To determine whether reduction of cholesterol by drug therapy significantly lowered the atherosclerotic coronary heart disease rate in a group of hypercholesterolemic but otherwise healthy men.

Total dollars spent on the CPPT from June 1973 were $142,250,000. We do not have a year-by-year breakdown.

Condition or disease Intervention/treatment Phase
Cardiovascular Diseases Coronary Disease Heart Diseases Myocardial Ischemia Drug: cholestyramine Behavioral: diet, fat-restricted Phase 3

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Study Type : Interventional  (Clinical Trial)
Allocation: Randomized
Masking: Double
Primary Purpose: Prevention
Study Start Date : June 1973
Actual Study Completion Date : October 1989

Resource links provided by the National Library of Medicine

Information from the National Library of Medicine

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Ages Eligible for Study:   35 Years to 59 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Men, ages 35-59. Type II hyperlipoproteinemia. Free from coronary heart disease.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00000488

Sponsors and Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
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OverallOfficial: Francois Abboud University of Iowa
OverallOfficial: Elizabeth Barrett-Connor University of California, San Diego
OverallOfficial: Reagan Bradford Oklahoma Medical Research Foundation
OverallOfficial: Marilyn Buzzard University of Minnesota
OverallOfficial: Gerald Cooper Centers for Disease Control and Prevention
OverallOfficial: John Farquhar Stanford University
OverallOfficial: Ivan Frantz University of Minnesota
OverallOfficial: Anne Goldberg Washington University School of Medicine
OverallOfficial: Frank Ibbott Bio-Science Laboratories
OverallOfficial: William, Insull Baylor College of Medicine
OverallOfficial: Robert Knoop University of Washington
OverallOfficial: Peter Kwiterovich Johns Hopkins University
OverallOfficial: John LaRosa George Washington University
OverallOfficial: J. Little University of Toronto
OverallOfficial: L. Sheffield University of Alabama at Birmingham
OverallOfficial: Dennis Sprecher University of Cincinnati
Study Data/Documents: Individual Participant Data Set  This link exits the ClinicalTrials.gov site
Identifier: LRC-CPPT
NHLBI provides controlled access to IPD through BioLINCC. Access requires registration, evidence of local IRB approval or certification of exemption from IRB review, and completion of a data use agreement.

Rifkind B, Goor R: The Lipid Research Clinics Coronary Primary Prevention Trial (LRC-CPPT). Drugs Affecting Lipid Metabolism, l5l-l57, Fumagalli R, Kritchevsky D, Paoletti R (Eds): Elsevier/North-Holland Biomedical Press, l980.
Knopp RH: Test of the Lipid Hypothesis: The Coronary Primary Prevention Trial (CPPT) of the Lipid Research Clinics Program. Proceedings of the Fifth International Symposium on Atherosclerosis, 509-512, Gotto, AM, Jr. (Ed.): Springer-Verlag, 1980.
Rifkind BM: The Lipid Research Clinics Coronary Primary Prevention Trial (CPPT). Heartbeat, 1:7-8, 1985.
Rifkind BM: The Lipid Research Clinics Coronary Primary Prevention Trial. In Shepherd G, et al (Eds). Lipoproteins and Coronary Heart Disease. London and Glasgow. Blantyre Printing Ltd.:109, 1986.

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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ClinicalTrials.gov Identifier: NCT00000488    
Other Study ID Numbers: 7
First Posted: October 28, 1999    Key Record Dates
Last Update Posted: April 14, 2016
Last Verified: April 2012
Additional relevant MeSH terms:
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Cardiovascular Diseases
Heart Diseases
Coronary Disease
Myocardial Ischemia
Pathologic Processes
Vascular Diseases
Cholestyramine Resin
Anticholesteremic Agents
Hypolipidemic Agents
Molecular Mechanisms of Pharmacological Action
Lipid Regulating Agents