Coronary Drug Project Mortality Surveillance
|
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
| ClinicalTrials.gov Identifier: NCT00000483 |
|
Recruitment Status :
Completed
First Posted : October 28, 1999
Last Update Posted : November 26, 2013
|
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
| Condition or disease | Intervention/treatment | Phase |
|---|---|---|
| Cardiovascular Diseases Coronary Disease Heart Diseases Myocardial Infarction Myocardial Ischemia | Drug: estrogen Drug: clofibrate Drug: dextrothyroxine sodium Drug: niacin | Not Applicable |
BACKGROUND:
Three of the CDP treatments (two doses of estrogen and dextrothyroxine) were stopped prematurely because of toxicity. At the time the treatments were stopped, it was thought that future assessment of the status of patients on those treatments would be important to evaluate long-term sequellae. Another clinical trial evaluating clofibrate for primary prevention found that more patients on that treatment than on placebo had died. This effect persisted even after the treatment was stopped. Therefore, it was considered necessary to follow the CDP patients on clofibrate.
Of the original 834l patients, about 6000 were still alive in March l975. Cause-specific mortality in those patients was assessed through March l980.
DESIGN NARRATIVE:
The vital status of the subjects known to be alive at the end of the CDP in March l975 was assessed as of March l980. This was accomplished through questioning the local investigators, letters to the subjects, and by use of Social Security Administration and National Death Index records.
The study completion date listed in this record was obtained from the Query/View/Report (QVR) System.
| Study Type : | Interventional (Clinical Trial) |
| Allocation: | Randomized |
| Primary Purpose: | Prevention |
| Study Start Date : | June 1981 |
| Actual Study Completion Date : | March 1985 |
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
| Ages Eligible for Study: | 30 Years to 64 Years (Adult) |
| Sexes Eligible for Study: | Male |
| Accepts Healthy Volunteers: | No |
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00000483
| OverallOfficial: | Roger Sherwin | University of Maryland |
| ClinicalTrials.gov Identifier: | NCT00000483 |
| Other Study ID Numbers: |
2 R01HL008888-14S1 ( Other Grant/Funding Number: US NIH Grant Number ) |
| First Posted: | October 28, 1999 Key Record Dates |
| Last Update Posted: | November 26, 2013 |
| Last Verified: | April 2004 |
|
Cardiovascular Diseases Myocardial Infarction Heart Diseases Coronary Disease Myocardial Ischemia Infarction Ischemia Pathologic Processes Necrosis Vascular Diseases Niacin Clofibrate Estrogens |
Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Physiological Effects of Drugs Hypolipidemic Agents Antimetabolites Molecular Mechanisms of Pharmacological Action Lipid Regulating Agents Vasodilator Agents Vitamin B Complex Vitamins Micronutrients Anticholesteremic Agents |