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Serotonin/Dopamine Antagonism of Cocaine Effect: 1 - 1

This study has been terminated.
(Unable to recruit adequate number of subjects)
National Institute on Drug Abuse (NIDA)
VA Boston Healthcare System
Information provided by (Responsible Party):
Lawrence H. Price, Butler Hospital Identifier:
First received: September 20, 1999
Last updated: July 23, 2015
Last verified: July 2015
The purpose of this study is to evaluate use of risperidone with cocaine abusers. Study measures incorporate an appropriate integration of behavioral and neurobiological indices.

Condition Intervention Phase
Cocaine-Related Disorders
Drug: Risperidone
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: Serotonin/Dopamine Antagonism of Cocaine Effect

Resource links provided by NLM:

Further study details as provided by Butler Hospital:

Primary Outcome Measures:
  • Analog mood scales
  • POMS
  • EPS sx

Estimated Enrollment: 0
Study Start Date: August 1994
Study Completion Date: January 2000
Primary Completion Date: January 2000 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Please contact site for information.
  Contacts and Locations
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Please refer to this study by its identifier: NCT00000309

United States, Rhode Island
Brown University School of Medicine
Providence, Rhode Island, United States, 2906
Sponsors and Collaborators
Butler Hospital
National Institute on Drug Abuse (NIDA)
VA Boston Healthcare System
Principal Investigator: Lawrence Price, M.D. Brown University
  More Information

Responsible Party: Lawrence H. Price, Professor of Psychiatry and Human Behavior, Butler Hospital Identifier: NCT00000309     History of Changes
Other Study ID Numbers: NIDA-09330-1  R01DA009330  R01-09330-1 
Study First Received: September 20, 1999
Last Updated: July 23, 2015
Health Authority: United States: Federal Government

Keywords provided by Butler Hospital:
cocaine abuse, cocaine addiction

Additional relevant MeSH terms:
Cocaine-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Cardiotonic Agents
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Dopamine Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Protective Agents
Serotonin Antagonists
Serotonin Agents
Antipsychotic Agents
Tranquilizing Agents
Central Nervous System Depressants
Psychotropic Drugs
Dopamine Antagonists
Serotonin Receptor Agonists
Anesthetics, Local
Sensory System Agents
Vasoconstrictor Agents
Dopamine Uptake Inhibitors processed this record on October 26, 2016