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A Laboratory Model for Heroin Abuse Medications - 8

This study has been completed.
Information provided by (Responsible Party):
New York State Psychiatric Institute Identifier:
First received: September 20, 1999
Last updated: November 4, 2013
Last verified: November 2013

The purpose of this study is to evaluate the effects of treatment medications (methadone, buprenorphine, LAAM, naltrexone, naltrexone microcapsules, and methoclocinnamox) on I.V. and smoked heroin self-administration."

Condition Intervention Phase
Heroin Dependence
Opioid-Related Disorders
Substance-Related Disorders
Drug: opiates
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Pharmacodynamics Study
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Caregiver, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Laboratory Model for Heroin Abuse Medications

Resource links provided by NLM:

Further study details as provided by New York State Psychiatric Institute:

Primary Outcome Measures:
  • Amount drug self-administered [ Time Frame: 90 minutes ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Subjective responses [ Time Frame: 90 min ] [ Designated as safety issue: No ]

Estimated Enrollment: 37
Study Start Date: August 1995
Study Completion Date: November 2005
Primary Completion Date: November 2005 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Opiate abuser Drug: opiates
prescription opioids
Other Names:
  • morphine
  • fentanyl
  • buprenorphine
  • oxycodone
  • methadone


Ages Eligible for Study:   18 Years to 45 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Please contact site for information.

  Contacts and Locations
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Please refer to this study by its identifier: NCT00000273

United States, New York
Columbia University
New York, New York, United States, 10032
Sponsors and Collaborators
New York State Psychiatric Institute
Principal Investigator: Herbert Kleber, M.D. New York State Psychiatric Institute
  More Information

Responsible Party: New York State Psychiatric Institute Identifier: NCT00000273     History of Changes
Other Study ID Numbers: #4857, 5P50DA009236-18, P50 DA009236-08
Study First Received: September 20, 1999
Last Updated: November 4, 2013
Health Authority: United States: Federal Government
United States: Institutional Review Board
United States: Food and Drug Administration

Additional relevant MeSH terms:
Heroin Dependence
Opioid-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders processed this record on March 03, 2015