Effects of Alcohol History on Effects of Nitrous Oxide - 9
This study has been completed.
Sponsor:
University of Chicago
Collaborator:
National Institute on Drug Abuse (NIDA)
Information provided by (Responsible Party):
University of Chicago
ClinicalTrials.gov Identifier:
NCT00000257
First received: September 20, 1999
Last updated: May 26, 2015
Last verified: May 2015
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Purpose
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To determine effects of alcohol history on the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers.
| Condition | Intervention |
|---|---|
|
Alcohol-Related Disorders Opioid-Related Disorders Substance-Related Disorders |
Drug: 0% N2O and 10% N2O Drug: 0% N2O and 20% N2O Drug: 0% N2O and 30% N2O Drug: 0% N2O and 40% N2O |
| Study Type: | Interventional |
| Study Design: | Allocation: Non-Randomized Intervention Model: Crossover Assignment Masking: Double Blind (Subject, Investigator) |
| Official Title: | Effects of Alcohol History on Effects of Nitrous Oxide |
Resource links provided by NLM:
Further study details as provided by University of Chicago:
Primary Outcome Measures:
- Choice of nitrous oxide vs placebo [ Time Frame: After 30 min inhalation each of N2O and placebo ] [ Designated as safety issue: No ]Two subject groups (light drinkers vs moderate drinkers) were asked to inhale a given conc of N2O and inhale a placebo, then choose for a third inhalation. The subject & the technician administering the inhalant were blinded. Testing was done at each dose.
| Enrollment: | 19 |
| Study Start Date: | September 1995 |
| Study Completion Date: | April 1997 |
| Primary Completion Date: | April 1997 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
| Active Comparator: Light drinkers | Drug: 0% N2O and 10% N2O Drug: 0% N2O and 20% N2O Drug: 0% N2O and 30% N2O Drug: 0% N2O and 40% N2O |
| Active Comparator: Moderate drinkers | Drug: 0% N2O and 10% N2O Drug: 0% N2O and 20% N2O Drug: 0% N2O and 30% N2O Drug: 0% N2O and 40% N2O |
Eligibility| Ages Eligible for Study: | 21 Years to 37 Years (Adult) |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Criteria
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Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00000257
Please refer to this study by its ClinicalTrials.gov identifier: NCT00000257
Locations
| United States, Illinois | |
| University of Chicago, Anesthesia & Critical Care | |
| Chicago, Illinois, United States, 60637 | |
Sponsors and Collaborators
University of Chicago
National Institute on Drug Abuse (NIDA)
Investigators
| Principal Investigator: | James Zacny, Ph.D. | University of Chicago |
More Information
Publications:
| Responsible Party: | University of Chicago |
| ClinicalTrials.gov Identifier: | NCT00000257 History of Changes |
| Other Study ID Numbers: | NIDA-08391-9 R01DA008391 R01-08391-9 |
| Study First Received: | September 20, 1999 |
| Last Updated: | May 26, 2015 |
| Health Authority: | United States: Federal Government |
Keywords provided by University of Chicago:
|
nitrous oxide subjective effects ethanol healthy volunteer |
Additional relevant MeSH terms:
|
Disease Substance-Related Disorders Opioid-Related Disorders Alcohol-Related Disorders Pathologic Processes Chemically-Induced Disorders Mental Disorders Nitrous Oxide Anesthetics, Inhalation |
Anesthetics, General Anesthetics Central Nervous System Depressants Physiological Effects of Drugs Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents |
ClinicalTrials.gov processed this record on September 30, 2016