Effects of Alcohol History on Effects of Nitrous Oxide - 9
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ClinicalTrials.gov Identifier: NCT00000257 |
Recruitment Status :
Completed
First Posted : September 21, 1999
Last Update Posted : May 28, 2015
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Alcohol-Related Disorders Opioid-Related Disorders Substance-Related Disorders | Drug: 0% N2O and 10% N2O Drug: 0% N2O and 20% N2O Drug: 0% N2O and 30% N2O Drug: 0% N2O and 40% N2O | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 19 participants |
Allocation: | Non-Randomized |
Intervention Model: | Crossover Assignment |
Masking: | Double (Participant, Investigator) |
Official Title: | Effects of Alcohol History on Effects of Nitrous Oxide |
Study Start Date : | September 1995 |
Actual Primary Completion Date : | April 1997 |
Actual Study Completion Date : | April 1997 |

Arm | Intervention/treatment |
---|---|
Active Comparator: Light drinkers |
Drug: 0% N2O and 10% N2O Drug: 0% N2O and 20% N2O Drug: 0% N2O and 30% N2O Drug: 0% N2O and 40% N2O |
Active Comparator: Moderate drinkers |
Drug: 0% N2O and 10% N2O Drug: 0% N2O and 20% N2O Drug: 0% N2O and 30% N2O Drug: 0% N2O and 40% N2O |
- Choice of nitrous oxide vs placebo [ Time Frame: After 30 min inhalation each of N2O and placebo ]Two subject groups (light drinkers vs moderate drinkers) were asked to inhale a given conc of N2O and inhale a placebo, then choose for a third inhalation. The subject & the technician administering the inhalant were blinded. Testing was done at each dose.

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Ages Eligible for Study: | 21 Years to 37 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00000257
United States, Illinois | |
University of Chicago, Anesthesia & Critical Care | |
Chicago, Illinois, United States, 60637 |
Principal Investigator: | James Zacny, Ph.D. | University of Chicago |
Responsible Party: | University of Chicago |
ClinicalTrials.gov Identifier: | NCT00000257 |
Other Study ID Numbers: |
NIDA-08391-9 R01DA008391 ( U.S. NIH Grant/Contract ) R01-08391-9 |
First Posted: | September 21, 1999 Key Record Dates |
Last Update Posted: | May 28, 2015 |
Last Verified: | May 2015 |
nitrous oxide subjective effects ethanol healthy volunteer |
Disease Substance-Related Disorders Opioid-Related Disorders Alcohol-Related Disorders Pathologic Processes Chemically-Induced Disorders Mental Disorders Narcotic-Related Disorders Nitrous Oxide |
Anesthetics, Inhalation Anesthetics, General Anesthetics Central Nervous System Depressants Physiological Effects of Drugs Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents |