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Differential Acute Tolerance Development to Effects of Nitrous Oxide - 7

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ClinicalTrials.gov Identifier: NCT00000255
Recruitment Status : Completed
First Posted : September 21, 1999
Last Update Posted : May 28, 2015
Sponsor:
Collaborator:
Information provided by (Responsible Party):

Study Description
Brief Summary:
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine differential acute tolerance development to effects of nitrous oxide in humans.

Condition or disease Intervention/treatment Phase
Opioid-Related Disorders Substance-Related Disorders Drug: Nitrous oxide Phase 2

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 10 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Official Title: Differential Acute Tolerance Development to Effects of Nitrous Oxide
Study Start Date : April 1995
Primary Completion Date : May 1996
Study Completion Date : May 1996

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arms and Interventions

Arm Intervention/treatment
Placebo Comparator: 0% Nitrous oxide Drug: Nitrous oxide
Active Comparator: 10% nitrous oxide Drug: Nitrous oxide
Active Comparator: 20% nitrous oxide Drug: Nitrous oxide
Active Comparator: 30% nitrous oxide Drug: Nitrous oxide
Active Comparator: 40% nitrous oxide Drug: Nitrous oxide


Outcome Measures

Primary Outcome Measures :
  1. Pain intensity, pain bothersomeness [ Time Frame: 25, 70, & 115 min of inhalation and 40 min post ]
    Subjects will inhale varying conc of nitrous oxide for 120 min with cold immersion of forearm at 25, 70, and 115 min and 40 min after inhalation. Pain intensity and bothersomeness will be assessed at each immersion.


Eligibility Criteria

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Ages Eligible for Study:   21 Years to 37 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria
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Contacts and Locations

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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00000255


Locations
United States, Illinois
University of Chicago, Anesthesia & Critical Care
Chicago, Illinois, United States, 60637
Sponsors and Collaborators
University of Chicago
National Institute on Drug Abuse (NIDA)
Investigators
Principal Investigator: James Zacny, Ph.D. University of Chicago
More Information

Publications:
Responsible Party: University of Chicago
ClinicalTrials.gov Identifier: NCT00000255     History of Changes
Other Study ID Numbers: NIDA-08391-7
R01DA008391 ( U.S. NIH Grant/Contract )
R01-08391-7
First Posted: September 21, 1999    Key Record Dates
Last Update Posted: May 28, 2015
Last Verified: May 2015

Keywords provided by University of Chicago:
nitrous oxide
acute tolerance
subjective effects
analgesia
psychomotor
healthy volunteer

Additional relevant MeSH terms:
Disease
Substance-Related Disorders
Opioid-Related Disorders
Pathologic Processes
Chemically-Induced Disorders
Mental Disorders
Nitrous Oxide
Anesthetics, Inhalation
Anesthetics, General
Anesthetics
Central Nervous System Depressants
Physiological Effects of Drugs
Analgesics, Non-Narcotic
Analgesics
Sensory System Agents
Peripheral Nervous System Agents