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Cold Water Immersion Modulates Reinforcing Effects of Nitrous Oxide - 2

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00000250
First Posted: September 21, 1999
Last Update Posted: May 28, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
National Institute on Drug Abuse (NIDA)
Information provided by (Responsible Party):
University of Chicago
  Purpose
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To evaluate: cold water immersion modulates the reinforcing effects of nitrous oxide in healthy volunteers.

Condition Intervention Phase
Opioid-Related Disorders Substance-Related Disorders Drug: 0% N2O Drug: 40% N2O Phase 2

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: Single (Participant)
Primary Purpose: Treatment
Official Title: Cold Water Immersion Modulates Reinforcing Effects of Nitrous Oxide

Resource links provided by NLM:


Further study details as provided by University of Chicago:

Primary Outcome Measures:
  • Subject's choice of intervention [ Time Frame: After sampling trials ]

Enrollment: 12
Study Start Date: December 1993
Study Completion Date: May 1995
Primary Completion Date: May 1995 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Lukewarm water
Subjects will immerse forearm in lukewarm water while inhaling 0% and 40% N2O in 2 sampling trials, then choose between intervntions for one choice trial
Drug: 0% N2O
Subjects will inhale 100% oxygen with no N2O for 25 min then immerse forearm in warm water and cold water
Drug: 40% N2O
Subjects will inhale 40% N2O then immerse forearm in warm water and cold water
Active Comparator: Ice cold water
Subjects will immerse forearm in ice cold water while inhaling 0% and 40% N2O in 2 sampling trials, then choose between intervntions for one choice trial
Drug: 0% N2O
Subjects will inhale 100% oxygen with no N2O for 25 min then immerse forearm in warm water and cold water
Drug: 40% N2O
Subjects will inhale 40% N2O then immerse forearm in warm water and cold water

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   21 Years to 32 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria
Please contact site for information.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00000250


Locations
United States, Illinois
University of Chicago, Anesthesia & Critical Care
Chicago, Illinois, United States, 60637
Sponsors and Collaborators
University of Chicago
National Institute on Drug Abuse (NIDA)
Investigators
Principal Investigator: James Zacny, Ph.D. University of Chicago
  More Information

Publications:
Experimentall Clinical Psycopharmacoly 1995, 3(2):148-155

Responsible Party: University of Chicago
ClinicalTrials.gov Identifier: NCT00000250     History of Changes
Other Study ID Numbers: NIDA-08391-2
R01DA008391 ( U.S. NIH Grant/Contract )
R01-08391-2
First Submitted: September 20, 1999
First Posted: September 21, 1999
Last Update Posted: May 28, 2015
Last Verified: May 2015

Keywords provided by University of Chicago:
nitrous oxide
choice
subjective effects
pain
analgesia
reinforcer
healthy volunteer

Additional relevant MeSH terms:
Disease
Substance-Related Disorders
Opioid-Related Disorders
Pathologic Processes
Chemically-Induced Disorders
Mental Disorders
Nitrous Oxide
Anesthetics, Inhalation
Anesthetics, General
Anesthetics
Central Nervous System Depressants
Physiological Effects of Drugs
Analgesics, Non-Narcotic
Analgesics
Sensory System Agents
Peripheral Nervous System Agents