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Effects of Subanesthetic Concentrations of Nitrous Oxide - 1

This study has been completed.
National Institute on Drug Abuse (NIDA)
Information provided by (Responsible Party):
University of Chicago Identifier:
First received: September 20, 1999
Last updated: May 26, 2015
Last verified: May 2015
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine effects of subanesthetic concentrations of nitrous oxide on cold-pressor pain in humans.

Condition Intervention Phase
Opioid-Related Disorders
Substance-Related Disorders
Drug: 20% N2O
Drug: 30% N2O
Drug: 40% N2O
Phase 2

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: Double Blind (Participant, Investigator)
Primary Purpose: Treatment
Official Title: Effects of Subanesthetic Concentrations of Nitrous Oxide

Resource links provided by NLM:

Further study details as provided by University of Chicago:

Primary Outcome Measures:
  • Pain intensity [ Time Frame: during cold test at 10 min & 30 min of inhalation ]
    Subjects immersed non-dominant arm for 3 minutes twice in 2-3 degree C water while inhaling 0 (placebo), 20, 30, or 40% N2O for a total of 40 minutes

Enrollment: 10
Study Start Date: September 1993
Study Completion Date: June 1995
Primary Completion Date: June 1995 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
No Intervention: Control
Subject inhaled 0% N2O for 40 minutes with cold immersion at 10 and 30 minutes
Active Comparator: 20% N2O
Subject inhaled 20% N2O for 40 minutes with cold immersion at 10 & 30 minutes
Drug: 20% N2O
20% inhaled N2O
Active Comparator: 30% N2O
Subject inhaled 30% N2O for 40 minutes with cold immersion at 10 and 30 minutes
Drug: 30% N2O
30% inhaled N2O
Active Comparator: 40% N2O
Subject inhaled 40% N2O for 40 minutes with cold immersion at 10 and 30 minutes
Drug: 40% N2O
40% inhaled N2O


Ages Eligible for Study:   21 Years to 37 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
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Please refer to this study by its identifier: NCT00000249

United States, Illinois
University of Chicago, Anesthesia & Critical Care
Chicago, Illinois, United States, 60637
Sponsors and Collaborators
University of Chicago
National Institute on Drug Abuse (NIDA)
Principal Investigator: James Zacny, Ph.D. University of Chicago
  More Information

Pharmocol Biochem and Behavior 1995, 51( 2): 323-329

Responsible Party: University of Chicago Identifier: NCT00000249     History of Changes
Other Study ID Numbers: NIDA-08391-1
R01DA008391 ( US NIH Grant/Contract Award Number )
Study First Received: September 20, 1999
Last Updated: May 26, 2015

Keywords provided by University of Chicago:
nitrous oxide
subjective effects
healthy volunteer

Additional relevant MeSH terms:
Substance-Related Disorders
Opioid-Related Disorders
Pathologic Processes
Chemically-Induced Disorders
Mental Disorders
Nitrous Oxide
Anesthetics, Inhalation
Anesthetics, General
Central Nervous System Depressants
Physiological Effects of Drugs
Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents processed this record on May 25, 2017