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Estrogen Hormone Protocol

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00000177
Recruitment Status : Completed
First Posted : November 1, 1999
Last Update Posted : December 11, 2009
Sponsor:
Information provided by:
National Institute on Aging (NIA)

Brief Summary:
Estrogen is a hormone that is dominant in the female reproductive system. In women, most estrogen is produced by the ovaries. Men produce estrogen by converting testosterone into estrogen. Because this hormone also has many beneficial effects on brain cells, it currently is being studied as a treatment for Alzheimer's disease. The enzyme that forms the neurotransmitter acetylcholine is promoted in the presence of estrogen. Several very small clinical studies have demonstrated improvement in cognitive function and mood measures in women with Alzheimer's disease who take estrogen.

Condition or disease Intervention/treatment Phase
Alzheimer Disease Drug: Estrogen Phase 3

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Study Type : Interventional  (Clinical Trial)
Enrollment : 120 participants
Allocation: Randomized
Masking: Double
Primary Purpose: Treatment
Study Start Date : October 1995
Actual Primary Completion Date : January 1999
Actual Study Completion Date : January 1999

Resource links provided by the National Library of Medicine

Drug Information available for: Estrogens





Information from the National Library of Medicine

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Ages Eligible for Study:   60 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Women with a diagnosis of Alzheimer's disease who currently are not taking estrogen replacement therapy, who have had a hysterectomy, and who are in stable general health.

Exclusion Criteria:

  • Patients with an uncontrolled health problem, such as untreated high blood pressure or thyroid disease.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00000177


Locations
Show Show 25 study locations
Sponsors and Collaborators
National Institute on Aging (NIA)
Investigators
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Principal Investigator: Leon Thal, MD. University of California, San Diego
Additional Information:
Publications of Results:
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ClinicalTrials.gov Identifier: NCT00000177    
Other Study ID Numbers: IA0001
3U01AG010483-08S2 ( U.S. NIH Grant/Contract )
First Posted: November 1, 1999    Key Record Dates
Last Update Posted: December 11, 2009
Last Verified: September 2009
Keywords provided by National Institute on Aging (NIA):
Alzheimer's disease
Estrogen
Additional relevant MeSH terms:
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Alzheimer Disease
Dementia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Tauopathies
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders
Estrogens
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs