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Alzheimer's Disease Prevention Trial

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ClinicalTrials.gov Identifier: NCT00000176
Recruitment Status : Completed
First Posted : November 1, 1999
Last Update Posted : November 5, 2010
Sponsor:
Information provided by:
National Institute on Aging (NIA)

Brief Summary:
This is a three-year study to determine if estrogens can prevent memory loss and Alzheimer's disease in women with a family history of Alzheimer's disease.

Condition or disease Intervention/treatment Phase
Alzheimer Disease Memory Disorders Drug: Estrogen Drug: Estrogen and Progesterone Phase 3

Detailed Description:
PREventing Postmenopausal memory loss and Alzheimer's with Replacement Estrogens (PREPARE) is a double-blind-placebo controlled trial to determine whether estrogen (or estrogen and progesterone) can delay the onset of memory loss or Alzheimer's Disease in elderly women with a family history of the disease.

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Study Type : Interventional  (Clinical Trial)
Allocation: Randomized
Masking: Double
Primary Purpose: Prevention
Official Title: Alzheimer's Disease Prevention Trial. A Multi-center, Randomized, Double-blind Placebo Controlled Trial of Estrogens to Prevent Alzheimer's Disease and Loss of Memory in Women.
Actual Primary Completion Date : September 2007
Actual Study Completion Date : September 2007

Resource links provided by the National Library of Medicine

Drug Information available for: Estrogens





Information from the National Library of Medicine

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Ages Eligible for Study:   65 Years and older   (Older Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy women 65 or older with a family history of memory problems not currently on estrogen.

Exclusion Criteria:

  • Significant neurological impairment
  • Current estrogen use
  • History of breast cancer

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00000176


Locations
Show Show 22 study locations
Sponsors and Collaborators
National Institute on Aging (NIA)
Investigators
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Principal Investigator: Mary Sano, PhD Icahn School of Medicine at Mount Sinai
Publications of Results:
Other Publications:
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ClinicalTrials.gov Identifier: NCT00000176    
Other Study ID Numbers: IA0018
RO 1AG15922-01
First Posted: November 1, 1999    Key Record Dates
Last Update Posted: November 5, 2010
Last Verified: November 2010
Keywords provided by National Institute on Aging (NIA):
Alzheimer's disease
memory loss
Estrogen
Additional relevant MeSH terms:
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Alzheimer Disease
Memory Disorders
Dementia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Tauopathies
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Progesterone
Estrogens
Progestins
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs