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Alzheimer's Disease Prevention Trial

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00000176
Recruitment Status : Completed
First Posted : November 1, 1999
Last Update Posted : November 5, 2010
Information provided by:
National Institute on Aging (NIA)

Brief Summary:
This is a three-year study to determine if estrogens can prevent memory loss and Alzheimer's disease in women with a family history of Alzheimer's disease.

Condition or disease Intervention/treatment Phase
Alzheimer Disease Memory Disorders Drug: Estrogen Drug: Estrogen and Progesterone Phase 3

Detailed Description:
PREventing Postmenopausal memory loss and Alzheimer's with Replacement Estrogens (PREPARE) is a double-blind-placebo controlled trial to determine whether estrogen (or estrogen and progesterone) can delay the onset of memory loss or Alzheimer's Disease in elderly women with a family history of the disease.

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Study Type : Interventional  (Clinical Trial)
Allocation: Randomized
Masking: Double
Primary Purpose: Prevention
Official Title: Alzheimer's Disease Prevention Trial. A Multi-center, Randomized, Double-blind Placebo Controlled Trial of Estrogens to Prevent Alzheimer's Disease and Loss of Memory in Women.
Actual Primary Completion Date : September 2007
Actual Study Completion Date : September 2007

Resource links provided by the National Library of Medicine

Drug Information available for: Estrogens

Information from the National Library of Medicine

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Ages Eligible for Study:   65 Years and older   (Older Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy women 65 or older with a family history of memory problems not currently on estrogen.

Exclusion Criteria:

  • Significant neurological impairment
  • Current estrogen use
  • History of breast cancer

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00000176

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United States, Alabama
University of Alabama
Birmingham, Alabama, United States, 35294
United States, California
University of California, Irvine
Irvine, California, United States, 29697-4540
United States, Connecticut
New England Center for Headache
Stamford, Connecticut, United States, 06902-1249
United States, District of Columbia
Howard University
Washington, District of Columbia, United States, 20060
United States, Florida
Lee Memorial Health System
Fort Myers, Florida, United States, 33901
Mayo Clinic Jacksonville
Jacksonville, Florida, United States, 32225
Wein Center
Miami Beach, Florida, United States, 33140
West Florida Regional Medical Center
Pensacola, Florida, United States, 32514
North Broward Medical Center
Pompano Beach, Florida, United States
Tallahassee Memorial Health Center
Tallahassee, Florida, United States, 32308
St. Mary's Medical Center
West Palm Beach, Florida, United States, 33407
United States, Maryland
Johns Hopkins Bayview Medical Center
Baltimore, Maryland, United States, 21224
United States, New Jersey
Neurology Group of Bergen County
Ridgewood, New Jersey, United States, 07450
United States, New York
Columbia University
New York, New York, United States, 10032
Cornell Medical Center, New York Presbyterian Medical Center
New York, New York, United States
New York United Hospital Medical Center
Port Chester, New York, United States, 10573
Burke Medical Research Institute
White Plains, New York, United States, 10605
United States, North Carolina
Duke University Medical Center
Durham, North Carolina, United States, 27710
United States, Oklahoma
Clinical Pharmaceutical Trials
Tulsa, Oklahoma, United States, 74104-5428
United States, Rhode Island
Butler Hospital, Rhode Island Hospital
Providence, Rhode Island, United States, 02906
United States, South Carolina
Medical University of South Carolina
North Charleston, South Carolina, United States, 29406
United States, Virginia
Eastern Virginia Medical School
Norfolk, Virginia, United States, 23507-1912
Sponsors and Collaborators
National Institute on Aging (NIA)
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Principal Investigator: Mary Sano, PhD Icahn School of Medicine at Mount Sinai

Publications of Results:
Other Publications:
Layout table for additonal information Identifier: NCT00000176     History of Changes
Other Study ID Numbers: IA0018
RO 1AG15922-01
First Posted: November 1, 1999    Key Record Dates
Last Update Posted: November 5, 2010
Last Verified: November 2010
Keywords provided by National Institute on Aging (NIA):
Alzheimer's disease
memory loss
Additional relevant MeSH terms:
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Alzheimer Disease
Memory Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Signs and Symptoms
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs