The Effects of Sex Hormones on Cognition and Mood in Older Adults
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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT00000175 |
Recruitment Status :
Terminated
First Posted : November 1, 1999
Last Update Posted : December 11, 2009
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Cognition Disorders Mood Disorders | Drug: Estrogen Drug: Testosterone | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Intervention Model: | Crossover Assignment |
Masking: | Double |
Primary Purpose: | Treatment |
Estimated Primary Completion Date : | June 2005 |
Estimated Study Completion Date : | June 2005 |


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Ages Eligible for Study: | 65 Years to 90 Years (Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Women and men aged 65-90 who have not received hormone replacement for the last three months.
Exclusion Criteria:
- Previous head injury with loss of consciousness for more than one hour.
- Men with a history of prostate cancer.
- Men on testosterone replacement within the past three months.
- Women with a history of breast or uterine cancer.
- Women on estrogen replacement within the past three months.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00000175
United States, Maryland | |
Gerontology Research Center | |
Baltimore, Maryland, United States, 21224 |
Principal Investigator: | Dr. Pauline Maki | National Institute on Aging, Gerontology Research Center |
ClinicalTrials.gov Identifier: | NCT00000175 |
Other Study ID Numbers: |
IA0016 |
First Posted: | November 1, 1999 Key Record Dates |
Last Update Posted: | December 11, 2009 |
Last Verified: | March 2004 |
Emotions Cognition Aging Memory |
Disease Mood Disorders Cognition Disorders Pathologic Processes Mental Disorders Neurocognitive Disorders |
Testosterone Estrogens Androgens Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Physiological Effects of Drugs |